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Dr Ana Camelo

Research Interests

I am interested in how type-2 immune responses are initiated in allergen-induced asthma. My lab has recently identified a novel innate cell type (nuocyte) that arises in IL-25 and IL-33 dependent immune responses, such as in helminth infection and asthma, and which secretes IL-13. My work focuses upstream of this process where I am trying to understand how the signalling pathway occurs from allergen exposure to initiation of lung inflammation. I have identified a receptor of the toll-like family in the surface of epithelial cells that is required for allergen binding and that this mechanism initiates IL-25 and IL-33 production by these cells, which then initiate the inflammatory cascade in the lungs.

Along with the asthma project, I have also used a model of type-2 colitis in mice where I found that blocking IL-25 signalling through neutralizing antibodies against IL-25 & IL-17BR improves clinical symptoms and gut inflammation, by limiting IL-13 production from NKT cells and nuocytes.

I currently work for MedImmune. Medimmune

Keywords

eosinophils ; cytokine/interleukin/chemokine receptors ; macrophages ; epithelial cells ; innate immunity ; natural killer T cells (NKT cells) ; T cells ; Th2 ; interleukin ; antibody responses ; animal models ; Gamma Delta T cells ; monocytes ; monoclonal antibodies ; antibody engineering ; neutrophils ; dendritic cells ; Toll-like receptors ; Toll receptors

Topics

  • lung immunology
  • allergy
  • gastroenterology

Collaborators

Key Publications

Camelo A, Barlow JL, Drynan LF, Wong SH, Pannel R, Mckenzie ANJ Blocking Il-25 signalling protects against gut inflammation in a type-2 model of colitis by suppressing nuocyte and NKT derived IL-13. J Gastroenterol. 2012 Apr 27.

Wong SH, Walker JA, Jolin HE, Drynan L.F, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, Mckenzie ANJ. Transcription factor RORα is critical for nuocyte development. Nature Immunology 13(3):229–36.

Garcia P, Clarke M, Vegiopoulos A, Berlanga O, Camelo A, Lorvellec M, Frampton J, (2008). Reduced c-Myb activity compromises HSCs and leads to a myeloproliferation with a novel stem cell basis. EMBO J, Apr 2009

Madureira P, Baptista M, Vieira M, Magalhaes V, Camelo A, Oliveira L, Ribeiro A, Tavares D, Trieu-Cuot P, Vilanova M, Ferreira P, (2007).Streptococcus agalactiae GAPDH is a virulence-associated immunomodulatory protein. J Immunol178, 1379–87