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Dr. Arianne Richard

Postdoc Research Associate

T cell immunology

Single-cell technologies


Research Interests

Supervisors: John Marioni and Gillian Griffiths

My research examines the activation and function of cytotoxic T lymphocytes. I am particularly interested in the regulatory networks underlying T cell activation and how these can be perturbed.

Keywords

single cell transcriptomics ; computational biology ; cytotoxic T cells (CTL) ; cell signalling ; CD8 T cells ; control of gene expression

Topics

  • immunology

Key Publications

Richard AC, Peters JE, Lee JC, Vahedi G, Schäffer AA, Siegel RM*, Lyons PA*, Smith KGC*. (2016) Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network. Genome medicine, 8(1):76.

Richard AC*, Ferdinand JR*, Meylan F*, Hayes ET, Gabay O, Siegel RM. (2015) The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator. J Leukoc Biol, 98(3):333.

Richard AC*, Tan C*, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F. (2015) The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL- 9-Producing T Cells. J Immunol, 194(8):3567.

Other Publications

Peters JE, Lyons PA, Lee JC, Richard AC, Fortune MD, Newcombe PJ, Richardson S, Smith KGC. (2016) Insight into genotype-phenotype associations through eQTL mapping in multiple cell types in health and immunemediated disease. PLoS Genet, 12(3):e1005908.

Richard AC, Lyons PA, Peters JE, Biasci D, Flint SM, Lee JC, McKinney EF, Siegel RM, Smith KG. (2014) Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation. BMC Genomics, 15(1):649.

Vahedi G, Richard AC, O’Shea JJ. (2014) Enhancing our understanding of asthma. Nat Immunol, 15(8):701.

Meylan F, Richard AC, Siegel RM. (2011) TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. Immunol Rev, 244(1):188.

Meylan F, Richard AC, Siegel RM. (2011) TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation. Immunol Rev, 244(1):188-96.

Fei J, Richard AC, Bronson JE, Gonzalez RL. (2010) Transfer RNA-mediated regulation of ribosome dynamics during protein synthesis. Nat Struct Mol Biol,18(9):1043.