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Dr Helen Baxendale

Departments

Papworth Hospital:
Consultant Clinical Immunology

Research Interests

B cell lineage and repertoire development; natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease. Immune development; Pneumococcal disease; Investigation and management of primary and secondary immunodeficiency.

Keywords

T helper cells ; immune development ; B cell lineage and repertoire development ; animal models ; memory cells

Topics

  • primary immunodeficiency
  • vaccines
  • lung immunology
  • secondary immunodeficiency
  • pediatric

Key Publications

Cohen JM, Wilson R, Shah P, Baxendale HE, Brown JS.Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG. Vaccine. 2013 May 1;31(19):2328-32.

Cohen JM, Chimalapati S, de Vogel C, van Belkum A, Baxendale HE, Brown JS. Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation. Vaccine. 2012 Jun 22;30(30):4453-9.

Cohen JM, Khandavilli S, Camberlein E, Hyams C, Baxendale HE, Brown JS. Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation. PLoS One. 2011;6(10):

Baxendale HE, Johnson M, Keating SM, Ashton L, Burbidge P, Woodgate S, Southern J, Miller E, Goldblatt D. Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccination. Vaccine 2010; 28: 6915-22.

Baxendale HE, Keating SM, Johnson M, Southern J, Miller E, Goldblatt D. 2010. The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly. Vaccine; 28: 4763-70.

Smith CM, Lo Passo C, Scuderi A, Kolberg J, Baxendale H, Goldblatt D, Oggioni MR, Felici F, Andrew PW. Peptide mimics of two pneumococcal capsular polysaccharide serotypes (6B and 9V) protect mice from a lethal challenge with Streptococcus pneumoniae., Eur J Immunol 2009; 39(6):1527-1535.

Jacobsen MC, Thiebaut R, Fisher C, Sefe D, Clapson M, Klein N, & Baxendale HE. 2008, Pediatric Human Immunodeficiency Virus Infection and Circulating IgD(+) Memory B Cells, J Infect Dis;198(4):481-485.