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Mr Kourosh Saeb-Parsy

Mr Kourosh  Saeb-Parsy

Kourosh Saeb-Parsy is accepting applications for PhD students.

Kourosh Saeb-Parsy is available for consultancy.


Office Phone: 01223 336979

Research Interests

Mr Kourosh Saeb-Parsy joined the Department of Surgery in 2007 as a Clinical Lecturer and was appointed as University Lecturer and Honorary Consultant Transplant Surgeon in 2012. He has also been a Fellow and Director of Studies in Clinical Medicine at Fitzwilliam College since 2003.

His collaborative, multidisciplinary and translational research program is focused on:

  • Function and immunogenicity of transplanted regenerative cellular therapies
  • Ischaemia-reperfusion injury in transplantation
  • Clinical outcomes after transplantation

Function and Immunogenicity of Regenerative Cellular Therapies

Kourosh Saeb-Parsy is part of a broad network local and national translational and multi-disciplinary academic collaborations focused on the in vivo function and immunogenicity of stem cells. He has long-standing collaborations in Cambridge with Prof Ludovic Vallier from the Cambridge Stem Cell Institute and Dr Meritxell Huch from the Gurdon Institute, focused on regenerative cellular therapies derived from induced pluripotent stem cells and adult tissue for the treatment of diabetes and liver disease.

He is the Principal Investigator for the BETA-Protect collaboration (www.BETA-Protect.life) which brings together investigators from Cambridge, London, Oxford, Edinburgh, Aberdeen, Edinburgh and Newcastle to investigate the immunogenicity of regenerative cellular therapies for the treatment of type I diabetes and to optimize personalized immunotherapies to prevent their rejection.

He is a co-investigator in the LSFM4LIFE European Consortium (www.LSFM4LIFE.eu) which aims to develop and optimize a promising regenerative cellular therapy for type I diabetes derived from adult pancreas tissue.

He is part of a multidisciplinary collaboration with Prof Nigel Slater from the Department of Chemical Engineering and Biotechnology in Cambridge to investigate a novel method for the cryopreservation of human haematopoietic stem cells (HSCs) and cellular aggregates, including pancreatic islets in collaboration with Mr John Casey from the Scottish Islet Laboratory.

Much of his research programme in regenerative medicine is underpinned by the use of human HSCs, including in collaboration with Dr Elisa Laurenti from the Cambridge Stem Cell Institute. A particular focus of his group is using human HSCs for the creation and characterization of experimental models of the human immune compartment, also known as ‘humanised mice’. He is the co-founder and coordinator of the annual UK Humanized Mouse Symposium (www.hms.event.cam.ac.uk), which aims to share expertise and encourage collaborations focused on the characterization and use of this important experimental model.

Ischaemia-Reperfusion Injury

Kourosh Saeb-Parsy has a long-standing collaboration with Dr Mike Murphy from the Cambridge MRC Mitochondrial Unit to investigate the mechanisms of ischaemia-reperfusion injury (IRI) in organ transplantation and to develop therapeutic approaches for its amelioration. His research utilizes a number of murine, porcine and human models of IRI in collaboration with Prof Mike Nicholson from the University of Cambridge and includes the use of deceased human organs retrieved but declined for transplantation.

He is one of the Investigators in the Mitochondrial Therapies Group (www.MTG.group.cam.ac.uk), which is focused on developing mitochondria-targeted strategies to minimize IRI in transplantation, myocardial infarction and stroke.

He co-founded and coordinates the annual UK Ex Vivo Normothermic Perfusion Symposium (www.evnp.event.cam.ac.uk), which aims to share expertise and encourage collaborations focused on the use of ex vivo organ perfusion in transplantation.

Translational Research Using Human Tissue

Kourosh Saeb-Parsy is the Principal Investigator on more than 10 studies with and National Research Ethical Committee (NREC) approval for the use of donor human tissue in research. He is the founder and Director of the Cambridge Biorepository for Translational Medicine (www.CBTM.group.cam.ac.uk), which was established to support world-class multidisciplinary research collaborations in Cambridge and beyond through the provision of infrastructure, expertise and access to fresh human tissue. This biorepository supports leading research by more than 10 laboratories in Cambridge focused on transplantation, regenerative medicine, cancer, developmental biology, metabolic sciences, immunology and gastrointestinal physiology.

Clinical Transplantation

Kourosh Saeb-Parsy is actively involved in a number of clinical transplantation studies including randomized control trials, cohort studies and retrospective service evaluations examining outcomes after kidney, pancreas and liver transplantation using local and national data.

He is part of a medico-legal academic collaboration with Dr Matthew Dyson and Dr Kathleen Liddell from the Faculty of Law at the University of Cambridge to explore the legal regulation of transplantation.

He is part of a collaboration with Prof Hamid Sabourian from the Department of Economics at the University of Cambridge to apply Game Theory to decision making and outcome prediction in transplantation.

Cambridge Collaborators

Department of Surgery

  • Prof J Andrew Bradley
  • Dr Eleanor Bolton
  • Dr Sarah Hosgood
  • Prof Michael Nicholson
  • Mr Gavin Pettigrew
  • Mr Raaj Praseedom
  • Prof Christopher Watson

Cambridge Stem Cell Institute

  • Dr Meritxell Huch
  • Dr Elisa Laurenti
  • Prof Ludovic Vallier

MRC Mitochondrial Biology Unit

  • Dr Michael Murphy

MRC Cancer Unit

  • Dr Christian Frezza

Department of Medicine

  • Dr Michael Allison
  • Dr Menna Clatworthy
  • Dr Will Gelson
  • Dr Thomas Kreig

Department of Chemical Engineering and Biotechnology

  • Dr Krish Mahbubani
  • Prof Nigel Slater

Department of Histopathology

  • Dr Rebecca Brais
  • Dr Susan Davies

 Department of Economics

  • Prof Hamid Sabourian

Faculty of Law

  • Dr Matthew Dyson
  • Dr Kathleen Liddell

Membership of Collaborative Research Groups

Coordination of National Meetings

Keywords

B cells ; migration ; antigen presentation ; T cell receptor (TCR) ; memory cells ; stem cell transplantation ; helper T cells ; cytotoxic T cells (CTL) ; allorecognition ; immunohistochemistry ; MHC class I ; T cells ; MHC class II ; human studies ; animal models ; circulation ; microscopy ; regulatory T cells ; fluorescence microscopy ; stem cells ; clinical immunology ; FACS ; dendritic cells

Topics

  • liver transplantation
  • transplantation
  • pancreatic transplantation
  • renal transplantation

Key Publications

Selected Publications (since 2012)

  • Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K (2015) Transplanting suboptimum organs: medico-legal implications. Lancet 386: 719-21.
  • Sampaziotis F, Brito MC, Bertero A, Madrigal P, Saeb-Parsy K, Soares F, Schrumpf E, Melum E, Karlsen TH, Bradley JA, Gelson WTH, Davies S, Baker A, Kaser A, Alexander GJ, Hannan NRF, Vallier L (2015) Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation. Nature Biotechnology 33: 845-52.
  • Dare A, Logan A, PrimeT, Rogatti S, Goddard M, Bolton E, Bradley JA, Pettigrew GJ, Murphy M, Saeb-Parsy K (2015) The mitochondria-targeted antioxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model. Journal of Heart and Lung Transplantation 34: 1471-80.
  • Barlow AD, Hamed MO, Mallon DH, Brais RJ, Gribble FM, Scott MA, Howat WJ, Bradley JA, Bolton EM, Pettigrew GJ, Hosgood SA, Nicholson ML, Saeb-Parsy K (2015) Use of ex vivo normothermic perfusion for quality assessment of discarded human donor pancreases. American Journal of Transplantation 15: 2475-82.
  • Mallon DH, Riddiough GE, Summers DM, Butler AJ, Callaghan CJ, Bradbury L, Saeb-Parsy K, Torpey N, Bradley JA, Pettigrew GJ (2015). Successful transplantation of kidneys from elderly circulatory death donors by using microscopic and macroscopic characteristics to guide single or dual implantation. American Journal of Transplantation 15: 2931-9.
  • Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431-5.
  • Dare AJ, Bolton EA, Pettigrew GJ, Bradley JA, Saeb-Parsy K, Murphy MP (2015) Protection against renal ischemia-reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ. Redox Biology 5:163-168.
  • Hamed MO, Chen Y, Pasea L, Watson CJ, Torpey N, Bradley JA, Pettigrew GJ, Saeb-Parsy K (2015) Early graft loss after kidney transplantation: risk factors and consequences. American Journal of Transplantation 15:1632-43.
  • Kosmoliaptsis V, Salji M, Bardsley V, Chen Y, Thiru S, Griffiths MH, Copley HC, Saeb Parsy K, Bradley JA, Torpey N, Pettigrew GJ (2015) Baseline donor chronic renal injury confers the same transplant survival disadvantage for DCD and DBD kidneys. American Journal of Transplantation 15:754-63.
  • Li J, Kent DG, Godfrey AL, Manning H, Nangalia J, Aziz A, Chen E, Saeb-Parsy K, Fink J, Sneade R, Hamilton T, Pask D, Silber Y, Zhao X, Ghevaert C, Liu P, Green AR (2014). JAK2V617F-homozygosity drives a phenotypic switch between myeloproliferative neoplasms in a murine model, but is insufficient to sustain clonal expansion. Blood 123:3139-51.
  • Dare A, Pettigrew GJ, Saeb-Parsy K (2014) Pre-operative assessment of the deceased donor kidney: from macroscopic appearance to molecular biomarkers. Transplantation 97:797-807.
  • Callaghan CJ, Harper SJ, Saeb-Parsy K, Hudson A, Gibbs P, Watson CJ, Praseedom RK, Butler AJ, Pettigrew GJ, Bradley JA (2014). The discard of deceased donor kidneys in UK. Clinical Transplantation 28:345-53.
  • Chubra M, Conlon T, Saeb-Parsy K, Pettigrew GJ (2013) BAFF and associated TNF superfamily members in renal transplantation: an end to Blysful ignorance. Transplantation (in press).
  • Sivaganesh S, Harper SJ, Conlon TM, Saeb-Parsy K, Negus MC, Motallebzadeh R, Bolton EM, Bradley JA, Pettigrew GJ (2013) Co-presentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells. Journal of Immunology 190:5829-38.
  • Conlon T, Cole J, Motallebzadeh J, Harper I, Callaghan C, Bolton E, Bradley JA, Saeb-Parsy K, Pettigrew GJ (2012) Unlinked memory helper responses promote long-lasting humoral alloimmunity. Journal of Immunology 189:5703-12.
  • Conlon TM, Saeb-Parsy K, Cole JL, Motallebzadeh R, Qureshi MS, Rehakova S, Negus MC, Callaghan CJ, Bolton EM, Bradley JA, Pettigrew GJ (2012). Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells. Journal of Immunology 15, 2643-52.