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Dr Martin Turner

Dr Martin Turner

Martin Turner is accepting applications for PhD students.

Martin Turner is available for consultancy.


Research Interests

We aim to characterise fundamental mechanisms controlling lymphocyte development and function. In the future, explaining how these are integrated will be an important step towards a systems level understanding of immunity. Genetically modified mice in which the functions of signalling pathways and RNA–binding proteins (RBP) can be controlled by conditional mutagenesis are one important research tool. We also use genome wide approaches to study RNA turnover and translation and to identify the targets of RBP. Our approach trains individuals who can combine molecular, cellular and in vivo skills with the ability to generate and interpret big data and apply these to tackle important biological questions.

Keywords

transgenesis ; B cells ; interleukin ; cytokines ; genetics ; B cell receptor (BCR) ; T cell receptor (TCR) ; development ; immunohistochemistry ; apoptosis ; activation ; calcium imaging ; T cells ; infection ; antibody responses ; animal models ; FACS ; gene targeting ; cell culture ; fluorescence microscopy ; lymphocytes, ; signalling ; microRNAs

Topics

  • influenza

Key Publications

Galloway, A., Saveliev, A., Łukasiak, S., Hodson, D.J., Bolland, D., Balmanno, K., Ahlfors, H., Monzón-Casanova, E., Ciullini-Mannurita, S., Bell, L.S., Andrews, S. R., Díaz-Muñoz, M.D., Cook, S. J., Corcoran, A. and Turner M. “RNA binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence". Science 352:453 PMID: 27102483

Nakagawa R, Leyland R, Meyer-Hermann M, Lu D, Turner M, Arbore G, Phan TG, Brink R, Vigorito E.  (2016). MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.  J. Clin. Invest. 126 (1):377-88. PMID: 26657861

Tan LY, Whitfield P, Llorian M, Monzon-Casanova E, Diaz-Munoz MD, Turner M, Smith CW. (2015). Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation. Nucleic Acids Res. 2015 May 4. pii: gkv429. [Epub ahead of print] PMID: 25940628

Diaz-Muñoz,. M. D., Bell, S.E., Fairfax, K., Monzon-Casanova, E., Cunningham, A.F. Gonzalez-Porta, M., Andrews, S.R., Bunik, V. I., Zarnack, K., Curk, T.,  Ward A. Heggermont, W.A., Heymans, S., Gibson, G.E.,. Kontoyiannis, D. L., Ule, J., and TurnerM.  (2015) HuR-dependent regulation of mRNA splicing is essential for the B cell antibody response. Nature Immunology (4):415-25. PMID: 25706746

Lu D., Nakagawa R., Lazzaro S., Staudacher P., Abreu-Goodger C., Henley T., Boiani S., Leyland R., Galloway A., Andrews S., Butcher G., Nutt S.L, Turner M*., Vigorito E*..  (2014) The miR-155/PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation. J. Exp. Med.  211:2183-98. PMID: 25288398

Turner M, Galloway A, Vigorito E.(2014) Noncoding RNA and its associated proteins as regulatory elements of the immune system. Nature Immunology. 15(6):484-91. doi: 10.1038/ni.2887.

Turner M., and Katsikis P. (2012) Regulation of gene expression by non-coding RNA Pillars in immunology commentary J. Immunol. PMID: 22723637

Hodson, D. J., Janas, M. L., Galloway, A. Bell, S.E., Andrews, S., Li, C.M., Pannell, R. Siebel, C.W., MacDonald, H. R., De Keersmaecker, K., Ferrando, A.A., Grutz, G.,and Turner, M. (2010). Deletion of the RNA-binding proteins zfp36L1 and zfp36L2 leads to perturbed thymic development and T-lymphoblastic leukaemia. Nature. Immunology. 11(8):717-724. PMID: 20622884.

Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LM, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, and Turner M, (2010). Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction. J. Immunol. 185: 4042–4052 PMID: 20826752.

Janas ML, Varano G, Gudmundsson K, Noda M, Nagasawa T, Turner M, (2010) Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4. J. Exp. Med. 207:247–61. PMID: 20038597

Vigorito E, Kerry L Perks, Cei Abreu-Goodger, Sam Bunting, Zou Xiang, Susan Kohlhaas, Partha P. Das, Eric A. Miska, Antony Rodriguez, Allan Bradley, Kenneth G. C. Smith, Cristina Rada, Anton J. Enright, Kai-Michael Toellner, Ian C. MacLennan and Turner, M. (2007). MicroRNA-155 regulates the generation of Immunoglobulin class-switched plasma cells.  Immunity 27:847-59.

Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M*, Bradley A*.  (2007)  Requirement of bic/microRNA-155 for normal immune function.  Science.  316:608-11