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Dr Maki Ohashi

Research Interests

I am interested in molecular mechanism of human immune defence; how invasive cells such as fetus trophoblast cells and tumor cells can escape from immune system.

Keywords

trophoblast ; PI3K ; MHC class I ; cellular transformation ; human studies ; natural killer receptors ; antigen presentation

Topics

  • cancer

Collaborators

Key Publications

Ohashi M, Hrstic P, Kowalewski P, Kennedy P, Boyle L, Sharkey A, Stevanović S , Moffett M and Trowsdale J. HLA-C-bound peptides on invasive trophoblast cells and interaction with KIR on maternal NK cells (in preparation).

Ohashi M, Eagle RA, Trowsdale J. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a GPI-linked isoform.  J Biol Chem. 2010 May 28;285(22):16408-15.

Traherne JA, Martin M, Ward R, Ohashi M, Pellett F, Gladman D, Middleton D, Trowsdale J. Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex. Hum Mol Genet. 2010 Mar 1;19(5):737-51.

Eagle RA, Flack G, Warford A, Martínez-Borra J, Jafferji I, Traherne JA, Ohashi M, Boyle LH, Barrow AD, Caillat-Zucman S, Young NT, Trowsdale J. Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. PLoS ONE. 2009;4(2)