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Epigenetics of human intestinal epithelial cell pathophysiology, Post-doctoral researcher, University of Cambridge, UK

Department of Paediatrics at the University of Cambridge,

 

 Applications are invited for the post of a Research Associate (Post-doctoral fellow) to join the group of Dr Matthias Zilbauer, Department of Paediatrics at the University of Cambridge, UK. Main research themes include investigation of epigenetic mechanisms (particularly DNA methylation) in intestinal health and disease (e.g. Inflammatory Bowel Diseases (IBD) and Necrotizing Enterocolitis (NEC)) as well as their potential use as clinically applicable biomarkers. 

Unique access to patient derived human tissue has allowed us to establish the human intestinal epithelial organoid culture model and generate a large tissue bank providing an ideal set up to translate basic science into clinical practice. 

The specific project can be tailored to the interest and background of the individual candidate but is likely to involve analyses of primary human cell samples, generation of human intestinal organoids derived from biopsies, as well as their genomic and epigenetic modification using CRISPR/Cas9. Importantly, given a large existing sample cohort and genome wide profiles generated from human tissue/cell samples, bioinformatic skills are highly desirable. 

Our laboratory is situated at Addenbrookes Hospital in the heart of the Cambridge Biomedical Research Campus (http://cambridge-biomedical.com) providing access to state of the art research facilities. In addition we benefit from strong established collaborations particularly to the Cambridge Stem Cell Institute (http://www.stemcells.cam.ac.uk) and the European Bioinformatic Institute (EBI). 

The ideal candidate will have a PhD, an outstanding skillset, evidence for academic excellence and a track record of successful research output. We are looking for someone who is innovative and has initiative and personal drive. The post requires someone who is enthusiastic, focused, and has a passion for cutting edge science. The post-holder will play a crucial part of the research team and need to liaise closely with the clinical team. They will be expected to lead aspects of the research theme independently, strengthen existing research links and develop new collaborations. 

Funds are available for a fixed term of 24 months. The successful candidate will be encouraged and supported to obtain external personal fellowship and grant support within 2 years. 

Applications should include a CV and a brief statement outlining key areas of expertise and reasons why you would like to join the group. Informal enquiries can be addressed to Dr Matthias Zilbauer (mz304@medschl.cam.ac.uk) Please quote reference RP10958 on your application and in any correspondence about this vacancy. 

Websites: 

http://paediatrics.medschl.cam.ac.uk/about-us/people/senior-academic-staff/dr-matthias-zilbauer 

http://www.stemcells.cam.ac.uk/researchers/affiliate-investigators/matthias-zilbauer 

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/12376/ 

The closing date for applications is 15 January 2017. The interview date is expected to be during the week commencing 23rd January 2017.

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