Submitted by Dr Tennie Videler on Tue, 30/12/2014 - 12:46
Functional drug screening reveals anticonvulsants as enhancers of
mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion
Carbamazepine reveals a novel mechanism of mTOR‐independent control of
autophagy that may be manipulated pharmacologically and provides proof of
principle that therapeutic autophagy stimulation can be an effective
strategy to treat multidrug‐resistant tuberculosis.