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Pippa Kennedy

Research Interests

Supervisor: Professor Ashley Moffett

Ashley Moffett's group researches how the pregnant uterus (decidua) regulates placentation. We are interested in how Natural Killer cells (the most abundant leukocytes in the decidua) interact with trophoblast and other decidual leukocytes. In particular, I am investigating whether KIR2DS5 and KIR2DL5 expressed by decidual Natural Killer cells can recognise ligands on trophoblast and promote trophoblast invasion.

Keywords

NK ; trophoblast ; decidua ; macrophages ; mucosal immunology ; KIR ; human studies ; cell culture ; natural killer cells ; monocytes ; natural killer receptors ; FACS ; binding assays

Topics

  • pre-eclampsia
  • reproductive immunology

Key Publications

Male V, Sharkey A, Masters L, Kennedy PR, Farrell LE, Moffett A. The effect of pregnancy on the uterine NK cell KIR repertoire. Eur J Immunol. 2011 Oct;41(10):3017-27.

Apps R, Sharkey A, Gardner L, Male V, Kennedy P, Masters L, Farrell L, Jones D, Thomas R,Moffett A. Ex vivo functional responses to HLA-G differ between blood and decidual NK cells. Mol Hum Reprod. 2011 Sep;17(9):577-86.