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Professor Linda Wicker

Professor Linda Wicker

Professor of Immunogenetics

Linda Wicker is accepting applications for PhD students.

Linda Wicker is available for consultancy.


Research Interests

Our group is focused on understanding the molecular and cellular mechanisms of autoimmune syndromes such as type 1 diabetes (T1D) by identifying and characterising the function of genes that contribute to disease susceptibility in both humans and mice.

Keywords

co-stimulation ; comparative immunology ; co-stimulatory molecules ; anergy ; protein purification ; immunosenescence ; migration ; confocal microscopy ; cytokine/interleukin/chemokine receptors ; antigen presentation ; T cell receptor (TCR) ; cytokines ; aging ; autoimmunity ; genetics ; B cell receptor (BCR) ; interleukin ; inflammation ; tolerance ; activation ; gene regulation ; antigen processing ; apoptosis ; alternative splicing ; T cells ; human studies ; animal models ; traffic ; suppression ; genetic analysis ; evolution ; circulation ; signal transduction ; SNPs (single nucleotide polymorphisms) ; cell culture ; clinical immunology ; FACS ; signalling ; statistical analysis

Topics

  • type 1 diabetes
  • autoimmunity

Collaborators

Key Publications

Our group is focused on understanding the molecular and cellular mechanisms of autoimmune syndromes such as type 1 diabetes (T1D) by identifying and characterising the function of genes that contribute to disease susceptibility in both humans and mice.

Other Publications

Esposito L, Hunter KM1, Clark J, Rainbow DB, Stevens H, Denesha J, Duley S, Dawson S, Coleman G, Nutland S, Bell GL, Moran C, Pekalski M, Todd JA, Wicker LS. Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles.  J Immunol. 2014 Jun 13. pii: 1303389. [Epub ahead of print]

Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, Koentgen F, Ridgway WM, Todd JA, Bluestone JA, Peterson LB, Mattner J, Wicker LS. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol. 2011 Jul 1;187(1):325-36.

Fraser HI, Dendrou CA, Healy B, Rainbow DB, Howlett S, Smink LJ, Gregory S, Steward CA, Todd JA, Peterson LB, Wicker LS. Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol. 2010 May 1;184(9):5075-84.

Fung E, Esposito L, Todd JA, Wicker LS. Multiplexed immunophenotyping of human antigen-presenting cells in whole blood by polychromatic flow cytometry. Nat Protoc. 2010 Feb;5(2):357-70.

Dendrou CA, V. Plagnol E, Fung JHM, Yang K, Downes JD, Cooper S, Nutland G, Coleman M, Himsworth M, Hardy O, Burren B, Healy NM, Walker K, Koch WH, Ouwehand JR, Bradley NJ, Wareham JA, Todd, and LS, Wicker. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nature Genetics 2009, 41:1011–1015.

Araki M, D. Chung S, Lui DB, Rainbow G, Chamberlain V, Garner KM, Hunter L, Vijayakrishnan LB, Peterson M, Oukka AH, Sharpe R, Sobel VK, Kuchroo and LS, Wicker. . Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in NOD mice. Journal of Immunology 2009, 183: 5146 -5157.

Ridgway WM, B. Healy LJ, Smink D, Rainbow and LS, Wicker. New tools for defining the ‘genetic background’ of inbred mouse strains. Nature Immunology 2007, 8:669–673.

Using multi-colour flow cytometry and blood samples from Cambridge BioResource donors, we have correlated an increased frequency of CD25+ naive CD4+ T cells (outlined in red on the figure) with susceptibility to type 1 diabetes and multiple sclerosis.