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Dr Dong Lu

Research Interests

My current research interest involves understanding how B cells differentiate and produce antibodies. More specifically, to evaluate how the molecular mechanism governs this differentiation program and how antibodies undergo class switch recombination.

My background includes work focusing on cancer, stem cells, hematopoietic stem cells and respiratory medicine.

Keywords

antibodies ; microRNA ; B cells ; cell differentiation ; plasma cells ; stem cells ; lymphocytes, ; cell development ; cancer

Key Publications

Lu D, Nakagawa R, Lazzaro S, Staudacher P, Abreu-Goodger C, HenleyT, Boiani S, LeylandR, Galloway A, Andrews S, ButcherG, NuttSL, Turner M, VigoritoE (2014) The miR-155/PU.1 axis acts on Pax5 to enable efficient B cell differentiation Journal of Experimental Medicine 211(11) 2183-98.

Chew SK, Lu D, Campos LS, Scott KL, Collinson A, Raine K, Hinton J, Teague JW, Jones D, Menzies A, Butler AP, Gamble J, O’Meara S, McLaren S, Chin L, Liu P, Futreal PA (2014) Polygenic in vivo validation of cancer mutations using transposons. Genome Biology 15(9):455.

Vigorito E, Kohlhass S, Lu D, Leyland R (2013) miR-155: An ancient regulator of the immune system. Immunol Rev 253(1): 146-57.

Lu D, Davis M, Abreu-Goodger C, Wang W, Siede J, Campos L, Vigorito E, Dunham I, Skarnes W, Enright A, Liu P (2012) microRNAs promote induced pluripotency through specific targets. PLoS One 7(8):e40938.

Davis MP, Abreu-Goodger C, van Dongen S, Lu D, Tate PH, Bartonicek N, Kutter C, Liu P, Skarnes WC, Enright AJ, Dunham I. (2012) Large-Scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. PLoS One 7(8):e41762.

Wang W, Yang J, Liu H, Lu D, Chen X, Zenonos Z, Campos L, Rad R, Guo G, Zhang S, Bradley A, Liu P (2011) Modulating retinoic acid signaling produces ground state iPSCs. Proc Natl Acad Sci 108(45) 18283-8.

Rad R, Rad L, Wang W, Cadinanos J, Vassiliou G, Rice S, Campos L, Yusa K, Banerjee R, Li MA, de la Rosa J, Strong A, Lu D, Ellis P, Conte N, Yang F, Liu P, Bradley A (2010) Cancer gene discovery in mice using piggybac transposon mutagenesis. Science 330(6007) 1104-7.

Li P, Burke S, Wang J, Chen X, Ortiz M, Lee S, Lu D, Campos L, Goulding D, Ng B, Dougan G, Huntly B, Gottens B, Jenkins N, Copeland N, Colucci F, Liu P (2010) Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science 329(5987) 85-89.

Wang W, Lin C, Lu D, Ning Z, Cox T, Melvin D, Wang X, Bradley A, Liu P (2008) Chromosomal transposition of PiggyBac in mouse embryonic stem cells. Proc Natl Acad Sci 105(27) 9290-5.

Lu D, Xie S, Sukkar M, Lu X, Kakkar VV, Scully M, Chung KF (2007) Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15. Am J Respir Cell Mol Biol. 37, 494-500.

Lu D, Chung KF, Xia M, Lu X, Scully M, Kakkar VV (2006) Integrin binding characteristics of the disintegrin-like domain of ADAM-15. Thromb Haemost. 96, 642-651