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Cambridge Immunology Network



Supervisor: Dr. Stefano Pluchino

I am interested in the interaction between extracellular RNA and the immune system. My research particularly focuses on the analysis of extracellular vesicles and exosomes as a carrier for micro RNA.


Key publications: 

F. Gessler, V. Voss, S. Duetzmann, V. Seifert, R. Gerlach, D. Koegel, Inhibition of TissueFactor signalling limits proliferation, migration and invasion of low and high grade glioma cells. Neuroscience 165 (2010) 1312-1322 

S. Duetzmann, F. Gessler, P. Harter, V. Seifert, R. Gerlach, D. Koegel, Recent evidence for a pro-migratory and pro-invasive function of the procoagulant Tissue Factor in malignant gliomas. Cell Adh Migr 2010 Oct 15; 4(4)

F. Gessler, V. Seifert, R. Gerlach, D. Koegel, TFPI-2 signalling plays a fundamental role in proliferation, cell death and invasion in low and high grade glioma cells. Neurosci Lett. 2011 Jun 15; 497(1)

Harter PN, S. Duetzmann, U. Drott, E. Hattingen, D. Capper, F. Gessler, C. Senft, V. Seifert, KH. Plate, D. Koegel, M. Mittelbronn, Anti-tissue factor (TF9-10H10) treatment reduces tumor cell invasiveness in a novel migratory glioma model. Neuropathology. 2013 Feb 5;

J. Mani, S. Vallo, S. Rakel, P. Antonietti, F. Gessler, R. Blaheta, G. Bartsch, M. Michaelis, J. Cinatl, A. Haferkamp and D Koegel, Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 2015 Apr 7; 15(1):224

P. Antonietti, F. Gessler, H. Duessmann, C. Reimertz, M. Mittelbronn, J. H. Prehn, D. Kögel, AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy irrespective of expression levels and the subcellular localisation of Bcl-xL and Bcl-2 in MCF7 cells.Biochim Biophys Acta. 2015 Dec 22

 Florian  Gessler
Not available for consultancy


Person keywords: 
extracellular vesicles
immune system