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Dr Pavel Riha

Research Interests

Supervisor: Professor Chris Rudd

The optimal activation of naive CD4+ T-cells requires two signals: the first from the T-cell receptor complex (TCR/CD3) and the second from co-receptors. In contrast to memory T-cells, co-stimulation of naive CD4+ T-cells depends only on CD28 signalling and to lesser extent on chemokines CCL21 and CXCL12 (SDF-1α), whose primary function is to induce chemotaxis. Despite the crucial importance of co-stimulation for an efficient CD4+ T-cell activation and consequent modulation of adaptive immune responses, the interplay between CD28 and G-protein-coupled multi-spanner chemokine receptor (GPCR) co-stimulation is unclear. Therefore, I am trying to elucidate the role of such dual co-stimulation in the regulation of proliferation, survival, motility and effector functions in CD4+ T-cells.

Keywords

co-stimulation ; co-stimulatory molecules ; anergy ; statistical analysis ; CCR7 ; cytokine/interleukin/chemokine receptors ; interleukin ; cytokines ; helper T cells ; chemokines/monokines ; T cell receptor (TCR) ; CXCR4 ; tolerance ; CD28 ; activation ; T cells ; animal models ; traffic ; suppression ; circulation ; cell culture ; FACS ; migration