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Cambridge Immunology Network



Supervisor: Klaus Okkenhaug

I investigate the role of the PI3K isotype p110δ in the immune response against tumours. There is evidence that the loss of p110δ function is protective against tumours in mice; my work attempts to elucidate the mechanism behind this protection, and how p110δ inhibition may be exploited in cancer therapy.




Key publications: 

Alex Yick-Lun So, Reeshelle Sookra1, Aadel A. Chaudhuri, Aarathi Minisandram, David Cheng, Catherine Xie, Ee Lyn Lim, Yvette Garcia Flores, Shuai Jiang, Jocelyn T. Kim, Christopher Keown, Parameswaran Ramakrishnan, and David Baltimore (2014) Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid and B cell leukemias Blood 2014 Jul 8. pii: blood-2014-02-553842. [Epub ahead of print] 

Ali K, Soond DR, Piñeiro R, Hagemann T, Pearce W, Lim EL, Bouabe H, Scudamore CL, Hancox T, Maecker H, Friedman L, Turner M, Okkenhaug K, Vanhaesebroeck B. (2014) Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.
Nature. 2014 Jun 11. doi: 10.1038/nature13444.

Mulin Jun Li, Panwen Wang, Xiaorong Liu, Ee Lyn Lim, Zhangyong Wang, Meredith Yeager, Maria P. Wong, Pak Chung Sham, Stephen J. Chanock, and Junwen Wang GWASdb: A database for human genetic variants identified by genome-wide association studies. Nucleic Acids Research, 2012 40(D1) D1047-D1054.

Gilberto Paz-Filho, Ee Lyn Lim, Ma-Li Wong1, Julio Licinio Associations between adipokines and obesity-related cancer. Frontiers in Bioscience, (2011)16(5) 1634-1650

 Ee Lyn  Lim
Not available for consultancy


Departments and institutes: 
Person keywords: 
tumour immunology