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Dr Daisuke Kashiwakuma

Research Interests

I am interested in mechanisms of autoimmunity, especially IL-21 production from CD4+ cells. It is reported that serum level of IL-21 is increased in many autoimmune diseases and inflammatory arthritis. My research aims to analyse IL-21 producing cells in inflammatory arthritis.

Keywords

IL-21 ; autoimmunity ; Tfh cells ; Th17 cells

Topics

  • autoimmune diseases
  • asthma

Key Publications

Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H. “B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent immune responses.”J Immunol. 2010 Sep 1;185(5):2730-6.

Hiramatsu Y, Suto A, Kashiwakuma D, Kanari H, Kagami S, Ikeda K, Hirose K, Watanabe N, Grusby MJ, Iwamoto I, Nakajima H. “c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T ells.” J Leukoc Biol. 2010 Apr;87(4):703-12. 

Suto A, Kashiwakuma D, Kagami S, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H. “Development and characterization of IL-21-producing CD4+ T cells.”J Exp Med. 2008 Jun 9;205(6):1369-79