Research
Our basic science research in the Department of Surgery focuses upon Transplant Immunology, with particular emphasis on the T cell allorecognition pathways and the role of B cells in allograft rejection and tolerance.
Publications
Sivaganesh S, Harper SJ, Conlon TM, Saeb-Parsy K, Negus MC, Motallebzadeh R, Bolton EM, Bradley JA, Pettigrew GJ. ‘Co-presentation of intact and processed MHC alloantigen by recipient dendritic cells enables delivery of linked help to alloreactive CD8 T cells by indirect-pathway CD4 T cells.’ J Immunol. 2013 Jun 1;190(11):5829-38
Callaghan CJ, Win TS, Motallebzadeh R, Conlon TM, Chhabra M, Harper I, Sivaganesh S, Bolton EM, Bradley JA, Brownlie RJ, Smith KGC, Pettigrew GJ. ‘Regulation of allograft survival by inhibitory FcgammaRIIb signaling’ J Immunology 2012 Dec 15;189(12):5694-702
Conlon TM, Cole JL, Motallebzadeh R, Harper I, Callaghan CJ, Bolton EM, Bradley JA, Saeb-Parsy K, Pettigrew GJ. ‘Unlinked memory helper responses promote long-lasting humoral alloimmunity’ J Immunology 2012 Dec 15;189(12):5703-12.
Conlon TM, Saeb-Parsy K, Cole JL, Motallebzadeh R, Qureshi MS, Rehakova S, Negus MC, Callaghan CJ, Bolton EM, Bradley JA, Pettigrew GJ. Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.J Immunol. 2012 Mar 15;188(6):2643-52.
Motallebzadeh R, Rehakova S, Conlon TM, Win TS, Callaghan CJ, Goddard M, Bolton EM, Ruddle NH, Bradley JA, Pettigrew GJ. Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses. FASEB J. 2012 Jan;26(1):51-62.
Win TS, Pettigrew GJ. Humoral autoimmunity and transplant vasculopathy: when allo is not enough. Transplantation. 2010 Jul 27;90(2):113-20.
Win TS, Rehakova S, Negus MC, Saeb-Parsy K, Goddard M, Conlon TM, Bolton EM, Bradley JA, Pettigrew GJ. Donor CD4 T cells contribute to cardiac allograft vasculopathy by providing help for autoantibody production. Circ Heart Fail. 2009 Jul;2(4):361-9.
Bolton EM, Bradley JA, Pettigrew GJ. Indirect allorecognition: not simple but effective.Transplantation. 2008 Mar 15;85(5):667-9.
Taylor AL, Negus SL, Negus M, Bolton EM, Bradley JA, Pettigrew GJ. Pathways of helper CD4 T cell allorecognition in generating alloantibody and CD8 T cell alloimmunity. Transplantation. 2007
CJ Callaghan, FJ Rouhani, MC Negus, AJ Curry, EM Bolton, JA Bradley, GJ Pettigrew. The abrogation of antibody-mediated allograft rejection by regulatory CD4 T cells with indirect allospecificity. J Immunol. 2007; 178: 221-8
