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Cambridge Immunology Network



Supervisor: Professor Ken Smith

Donor-specific HLA alloantibodies may cause acute and chronic antibody-mediated rejection (AMR) and significantly compromise allograft survival. The clinical relevance of antibodies directed against some HLA class II antigens, particularly HLA-DP, is less clear with conflicting reports on their pathogenicity.


Key publications: 

Wallin EF, Jolly EC, Suchánek O, Bradley JA, Espéli M, Jayne DR, Linterman MA, Smith KG. Human T follicular helper and T follicular regulatory cell maintenance is independent of germinal centers. Blood. 2014 Sep 15. pii: blood-2014-07-585976. 

Jolly EC, Key T, Rasheed H, Morgan H, Butler A, Pritchard N, Taylor CJ, Clatworthy MR. Preformed Donor HLA-DP-Specific Antibodies Mediate Acute and Chronic Antibody-Mediated Rejection Following Renal Transplantation. Am J Transplant. 2012 Oct;12(10):2845-8.

Willcocks LC, Lyons PA, Clatworthy MR, Robinson JI, Yang W, Newland SA, Plagnol V, McGovern NN, Condliffe AM, Chilvers ER, Adu D, Jolly EC, Watts R, Lau YL, Morgan AW, Nash G, Smith KG. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med. 2008 Jul 7;205(7):1573-82.

Hanif F, Abayasekara K, Willcocks L, Jolly EC, Jamieson NV, Praseedom RK, Goodacre JA, Read JC, Chaudhry A, Gibbs P. The quality of information about kidney transplantation on the World Wide Web. Clin Transplant. 2007 May-Jun;21(3):371-6.

Dr Elaine   Jolly
Not available for consultancy


Person keywords: 
expression level