Group Leader Immunogenomics of inflammatory bowel disease (Spinak Fellow) - Garvan-Weizmann Centre for Cellular Genomics (GWCCG) – Research
Research
Kylie James is a postdoctoral fellow at the Wellcome Sanger Institute in the laboratory of Sarah Teichmann and Junior Research Fellow at Christ's College, University of Cambridge. An immunologist by trade, her research passion lies in understanding how a body’s immune cells behave in a healthy state and how they combat or contribute to disease. In her doctorate at the University of Queensland, she investigated mechanisms shaping the response of T helper cells to malaria. In her current position, Kylie
applies single-cell approaches to study the immune environment of the human gut and importantly how it changes in relation to the neighbouring microbiome. Kylie’s work also contributes to a large international collaboration - the Human Cell Atlas - that aims to create the first comprehensive map of all cells in the human body.
Publications
Key publications:
- James KR, Gomes T, Elmentaite R, Kumar N, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polanski K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA, “Distinct microbial and immune niches of the human colon”, Nat Immunol. 2020 Feb 17. doi: 10.1038/s41590-020-0602-z.
- Efremova M*, Vento-Tormo R*, Park JE*, Teichmann SA, James KR, “Immunology in the era of single-cell technologies”, Annu. Rev. Immunol., In Press
- James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Engel JA, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A, Interferon Regulatory Factor 3 balances Th1 and Tfh-immunity during non-lethal blood-stage Plasmodium infection. J Immunol. (2018) 15 200(4) 1443-1456.
- Kunz DJ, Gomes T, James KR, Immune Cell Dynamics Unfolded by Single-Cell Technologies, Front. Immunol. (2018)
- Lonnberg T*, Svensson V*, James KR*, Fernandez-Ruiz D, Sebina I, Montandon R, Soon MSF, Fogg LG, Nair AS, Liligeto UN, Stubbington MJT, Ly LH, Bagger FO, Zweissele M, Lawrence ND, Souza-Fonseca-Guimaraes F, Bunn PT, Engwerda CR, Heath WR, Billker O, Stegel O, Haque A, Teichmann SA, Single-cell RNA-sequencing resolves a CD4+ T helper cell fate bifurcation. Sci Immunol (2017) 2 9
- Fernandez-Ruiz D, Lau LS, Ghazanfari N, Jones CM, Ng WY, Davey GM, Berthold D, Holz L, Kato Y, Enders MH, Bayarsaikhan G, Hendriks SH, Lansink LIM, Engel JA, Soon MSF, James KR, Cozijnsen A, Mollard V, Uboldi AD, Tonkin CJ, de Koning-Ward TF, Gilson PR, Kaisho T, Haque A, Crabb BS, Carbone FR, McFadden GI, Heath WR. Development of a Novel CD4+ TCR Transgenic Line That Reveals a Dominant Role for CD8+Dendritic Cells and CD40 Signaling in the Generation of Helper and CTL Responses to Blood-Stage Malaria. J Immunol. (2017) 199 12 4165-4179
- Khoury DS, Cromer D, Elliott T, Soon MSF, Thomas BS, James KR, Best SE, Aogo RA, Engel JA, Gartlan KH, Akter J, Sebina I, Haque A, Davenport MP. Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. Int J Parasitol (2017) 47 14 913-922
- Khoury DS, Cromer D, Akter J, Sebina I, Elliott T, Thomas BS, Soon MSF, James KR, Best SE, Haque A, Davenport MP. Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection. Proc Natl Acad Sci (2017) 114 29 7701-7706
- Sebina I, James KR, Soon MSF, Fogg LG, Best SE, de Labastida Rivera F, Montes de Oca M, Amante FH, Thomas BS, Beattie L, Souza-Fonseca-Guimaraes F, Smyth MJ, Hertzog PJ, Hutloff A, Hill GR, Engwerda CR, Haque A, Type I Interferon-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Path (2016) 12 11
- Proserpio V, Piccolo A, Haim-Vilmovsky L, Kar G, Lonnberg T, Svensson V, Pramanik J, Natarajan KN, Zhai W, Zhang X, Donati G, Kayikci M, Kotar J, McKenzie AN, Montandon R, James KR, Fernandez-Ruiz D, Heath WR, Haque A, Billker O, Woodhouse S, Cicuta P, Nicodemi M, Teichmann SA, Single cell analysis of CD4+ T cell differentiation reveals three major cell states and progressive acceleration of proliferation. Genome Biol (2016) 17 1 133
- Khoury D, Cromer D, Best S, James KR, Sebina I, Haque A, Davenport M, Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria. Sci Rep (2015) 6 5 9412
- Edwards C, Zhang V, Werder R, Best S, Sebina I, James KR, Faleiro R, de Labastida Rivera F, Amante F, Enwerda C,Phipps S, Haque A, Coinfection with blood-stage Plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung. Clin Vaccine Immunol (2015) 5 477-83
- Edwards C, Best S, Gun S, Claser C, James KR, de Oca M, Sebina I, de Labastida Rivera F, Amante F, Hertzog P, Engwerda C, Renia L, Haque A, Spatiotemporal requirements of IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection, Eur J Immunol (2015) 45 1 130-41
- Haque A, Best S, Montes de Oca, M, James KR, Ammerdorffer A, Edwards C, Rivera F, Amante F, Bunn P, Sheel M, Sebina I, Koyama M, Varelias A, Hertzog P, Kalinke U, Gun S, Rénia L, Ruedl C, MacDonald K, Hill G, Engwerda C. Type I IFN blockade in CD8- DC enhances Th1-immunity to malaria. J Clin Invest (2014) 124 6 2483-96
- Khoury D, Cromer D, Best S, James KR, Kim P, Engwerda C, Haque A, Davenport M. Effect of mature blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria. Infection and Immunity. (2014) 82 1 212-20
- Bunn P, Stanley A, Rivera F, Mulherin A, Sheel M, Alexander C, Faleiro R, Amante F, Montes De Oca M, Best S, James KR, Kaye P, Haque A, Engwerda C. Tissue requirements for establishing long-term CD4+ T cell-mediated immunity following Leishmania donovani infection. J Immunol. (2014) 192 8 3709-18
- Anthony B, James KR, Gobert G, Ramm G, McManus D. Schistosoma japonicum eggs induce a proinflammatory, anti-fibrogenic phenotype in hepatic stellate cells. PLOS One. (2013) 8 6
*equal contribution
