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Cambridge Immunology Network



Supervisor: Andrew McKenzie

Type-2 immune responses are important for combating parasitic worm infections but can also result in allergies and asthma. Molecules involved in the initiation of type-2 immune responses can serve as potential targets for therapeutic intervention. Interleukin-33 (IL-33) has been shown to be a potent inducer of type-2 inflammatory response mainly through its effects on T1ST2 receptor expressing immune cells. However, the mechanisms of its secretion and possible nuclear function in the IL-33 producing cells remain to be elucidated. My work focuses on the molecular mechanisms of IL-33 action in a context of an inflammatory response.


Key publications: 

Barlow JL, Peel S, Fox J, Panova V, Hardman CS, Camelo A, Bucks C, Wu X, Kane CM, Neill DR, Flynn RJ, Sayers I, Hall IP, McKenzie AN. IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. J Allergy Clin Immunol. 2013 Oct;132(4):933-41.

Hardman CS, Panova V, McKenzie AN. IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation. Eur J Immunol. 2013 Feb;43(2):488-98.

Wong, S.H., Walker, J.A., Jolin, H.E., Drynan, L.F., Hams, E., Camelo, A., Barlow, J.L., Neill, D.R., Panova, V., Koch, U., Radtke, F., Hardman, C.S., Hwang, Y.Y., Fallon, P.G. and McKenzie, A.N.J. . The transcription factor RORa is critical for nuocyte development. Nat. Immunol. 2012 13:229–236.

 Veera   Panova
Not available for consultancy


Departments and institutes: 
Person keywords: 
gene targeting
type-2 immunity
confocal microscopy