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Cambridge Immunology Network

 

Research

Biomarker studies in ANCA-associated vasculitis, lupus and immune-mediated renal disease.

I have been using proteomic platforms to investigate peptide expression signatures in renal transplantation specifically in chronic allograft dysfunction and antibody mediated rejection and currently we conduct a pilot study to identify protein biomarkers of lupus nephritis. We perform state-of-the-art proteomic analyses on plasma and urine samples of patients with systemic lupus erythematosus with or without lupus nephritis.

Publications

Key publications: 

Gómez-Puerta JA, Quintana LF, Stone JH, Ramos-Casals M, Bosch X. B-cell depleting agents for ANCA vasculitides: a new therapeutic approach. Autoimmun Rev. 2012 Jul;11(9):646-52.

Quintana LF, Bañon-Maneus E, Solé-Gonzalez A, Campistol JM. Urine proteomics biomarkers in renal transplantation: an overview. Transplantation. 2009 Aug 15;88(3 Suppl):S45-9.

Quintana LF, Campistol JM, Alcolea MP, Bañon-Maneus E, Sol-González A, Cutillas PR. Application of label-free quantitative peptidomics for the identification of urinary biomarkers of kidney chronic allograft dysfunction. Mol Cell Proteomics. 2009 Jul;8(7):1658-73

Quintana LF, Solé-Gonzalez A, Kalko SG, Bañon-Maneus E, Solé M, Diekmann F, Gutierrez-Dalmau A, Abian J, Campistol JM. Urine proteomics to detect biomarkers for chronic allograft dysfunction. J Am Soc Nephrol. 2009 Feb;20(2):428-35.

Quintana LF, Serra N, De Molina-Llauradó P, Blasco M, Martinez M, Campos B, Bayas JM, Pumarola T, Campistol JM. Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza Other Respir Viruses. 2013 Sep;7(5):809-14.

Quintana LF, Guzmán B, Collado S, Clària J, Poch E. A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE. Kidney Int. 2006 Feb;69(3):526-30.

Dr Luis   F. Quintana
Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
clinical immunology
proteomics
urine biomarkers
human studies