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Cambridge Immunology Network



Supervisor: Michelle Linterman

In response to infection or vaccination, germinal centre responses generate long-lived antibody secreting plasma cells and memory B cells. Vaccination programs have utilised this to efficiently protect against previously fatal infectious diseases. Despite these advances in preventive medicine, protecting aged individuals against seasonal epidemics such as influenza has proven difficult as their ability to generate a robust, protective memory after vaccination is strongly reduced. My project will investigate how cellular and molecular changes that occur in T cells in response to ageing contribute to the decline in the strength of immune responses.


 Michael  Shannack
Not available for consultancy


Departments and institutes: 
Person keywords: 
Tfh cells
cellular senescence
T follicular helper (Tfh) cell
germinal center