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Timon Adolph

Research Interests

Supervisor: Professor Arthur Kaser

My research interest lies in mucosal immunology and how environmental influences modulate a genetically susceptible host in inflammatory bowel disease. I am particularly interested in the intestinal epithelium and how derangements within this compartment (e.g. endoplasmic reticulum stress) might contribute to intestinal inflammation.

Keywords

gastroenterology ; epithelial cells ; microbiota ; unfolded protein response ; mucosal immunology ; endoplasmic reticulum stress

Topics

  • inflammatory bowel disease

Key Publications

Adolph TE, Tomczak MF, Niederreiter L, Ko H-J, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, .... Kaser A & Blumberg RS. Paneth cells as a site of origin for intestinal inflammation Nature  (2013)  doi:10.1038/nature12599 Published online 02 October 2013

Niederreiter L, Fritz TMJ, Adolph TE, Krismer A-M, Offner FA, Tschurtschenthaler M, Flak, MB, Hosomi, S, Tomczak MF, Kaneider NC, Sarcevic E, Kempster SL, Raine T, Esser, D, Roaenstiel P, Kohno K, Iwawaki T, Tilg H, Blumberg RS & Kaser A. ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells JEM 2013; 210 (10): 2041

Adolph TE, Niederreiter L, Blumberg RS, Kaser A. Endoplasmic reticulum stress and inflammation. Dig Dis. 2012;30(4):341-6.

Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A. Crohn's disease: NOD2, autophagy and ER stress converge. Gut. 2011 Nov;60(11):1580-8.

Paneth cell, lysozyme immunofluorescence confocal miscroscopy