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The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.

last modified Sep 15, 2015 01:56 PM
Christopher Rudd and colleagues have recently had a paper published in Molecular Cell on a new pathway that regulates T-cell activation.

It is a new way of viewing signaling in T-cells, directly at the compartmentalized level of the nuclear pore complex (NPC). 40-50% of all NFATc1 and NFkb nuclear entry in T-cells is controlled by this new pathway.
Liu H, Schneider H, Recino A, Richardson C, Goldberg MW, Rudd CE.

Mol Cell. 2015 Aug 26. pii: S1097-2765(15)00573-0. doi:
10.1016/j.molcel.2015.07.015

Please click here to access the paper

The new Jeffrey Cheah Biomedical Centre - CITIID

See the home of CITIID being built in this fantastic time-lapse video. From basement to water tight in 17 months. The Jeffrey Cheah Bimedical Centre is now complete and home to the Cambridge Immunology Network Coordinator.

Fibroblast

‘Fibroblast’ has been developed from a conversation between Harold Offeh and Dr Alice Denton, a scientist based at the Babraham Institute and a member of the Cambridge Immunology Network. Offeh was particularly interested in the character and roles played by particular cells in the immune system, as well as the immune system’s role as a primary source of protection and care. The film takes as a starting point microscopic images of broblast cells, an area of research for Dr Denton.

FCEs provide interdisciplinary training programmes for students, fellows and continuing education physicians through FOCIS assisted opportunities

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