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Andres Floto et al repurpose anticonvulsants as tuberculosis drug

last modified Dec 30, 2014 12:46 PM
Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Functional drug screening reveals anticonvulsants as enhancers of
mTOR‐independent autophagic killing of Mycobacterium tuberculosis through
inositol depletion


Carbamazepine reveals a novel mechanism of mTOR‐independent control of
autophagy that may be manipulated pharmacologically and provides proof of
principle that therapeutic autophagy stimulation can be an effective
strategy to treat multidrug‐resistant tuberculosis.