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Cambridge Immunology Network



B cell lineage and repertoire development; natural and vaccine induced immunity to streptococcus pneumonia in health and chronic disease. Immune development; Pneumococcal disease; Investigation and management of primary and secondary immunodeficiency.


Key publications: 

Cohen JM, Wilson R, Shah P, Baxendale HE, Brown JS.Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG. Vaccine. 2013 May 1;31(19):2328-32.

Cohen JM, Chimalapati S, de Vogel C, van Belkum A, Baxendale HE, Brown JS. Contributions of capsule, lipoproteins and duration of colonisation towards the protective immunity of prior Streptococcus pneumoniae nasopharyngeal colonisation. Vaccine. 2012 Jun 22;30(30):4453-9.

Cohen JM, Khandavilli S, Camberlein E, Hyams C, Baxendale HE, Brown JS. Protective contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17-cell responses to nasopharyngeal colonisation. PLoS One. 2011;6(10):

Baxendale HE, Johnson M, Keating SM, Ashton L, Burbidge P, Woodgate S, Southern J, Miller E, Goldblatt D. Circulating pneumococcal specific plasma and memory B cells in the elderly two years after pneumococcal conjugate versus polysaccharide vaccination. Vaccine 2010; 28: 6915-22.

Baxendale HE, Keating SM, Johnson M, Southern J, Miller E, Goldblatt D. 2010. The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly. Vaccine; 28: 4763-70.

Smith CM, Lo Passo C, Scuderi A, Kolberg J, Baxendale H, Goldblatt D, Oggioni MR, Felici F, Andrew PW. Peptide mimics of two pneumococcal capsular polysaccharide serotypes (6B and 9V) protect mice from a lethal challenge with Streptococcus pneumoniae., Eur J Immunol 2009; 39(6):1527-1535.

Jacobsen MC, Thiebaut R, Fisher C, Sefe D, Clapson M, Klein N, & Baxendale HE. 2008, Pediatric Human Immunodeficiency Virus Infection and Circulating IgD(+) Memory B Cells, J Infect Dis;198(4):481-485.

Dr Helen  Baxendale
Not available for consultancy


Departments and institutes: 
Person keywords: 
T helper cells
immune development
B cell lineage and repertoire development
animal models
memory cells