Research
My lab is interested in how immune-related membrane proteins are trafficked to the cell surface. We are particularly focussed on how the lipid composition of membranes might modify the abundance and activity of these cell surface proteins. We are also interested in how lipid antigens are loaded onto CD1 before being presented on the cell surface.
Publications
Key publications:
- Shamin, M., Benedyk, T.H., Graham, S.C. and Deane, J.E. (2019) “The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading” Wellcome Open Res. 2019, 4:117.
- Hill, C.H., Cook, G.M., Spratley, S.J., Fawke, S. Graham, S.C. and Deane, J.E. (2018) “The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure” Nat. Comms 9:151.
- Ilca, F.T., Neerincx, A., Hermann, C., Marcu, A., Stevanovic, S., Deane, J.E. and Boyle, L.H. (2018) “TAPBPR mediates peptide dissociation from MHC class I using a leucine lever” eLife pii: e40126.
- Neerincx, A., Hermann, C., Antrobus, R., van Hateren, A., Cao, H., Trautwein, N., Stevanović, S., Elliott, T., Deane, J.E. and Boyle, L.H. (2017) “TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway” eLife pii: e23049.
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