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Cambridge Immunology Network



I am interested in cell autonomous immunity, in particular anti-bacterial autophagy and immune signalling.


Key publications: 


The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria. 

Boyle KB, Ravenhill BJ, von Muhlinen N, Ellison CJ, Masson GR, Otten EG, Foeglein A, Williams R, Randow F

Mol Cell. 2019;74(2):320–329.e6. 


GBPs Inhibit Motility of Shigella flexneri but Are Targeted for Degradation by the Bacterial Ubiquitin Ligase IpaH9.8. 

Wandel WP, Pathe C, Werner EI, Ellison CJ, Boyle KB, von der Malsburg A, Rohde J, Randow F

Cell Host Microbe. 2017;22(4):507–518.e5. 


CALCOCO2/NDP52 initiates selective autophagy through recruitment of ULK and TBK1 kinase complexes. 

Boyle KB, Ravenhill BJ, Randow F. 

Autophagy. 2019;15(9):1655–1656.


Measuring Antibacterial Autophagy. 

Boyle KB, Randow F.

Methods Mol Biol. 2019;1880:679–690. 


Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy. 

Thurston TLM, Boyle KB, Allen M, Ravenhill BJ, Karpiyevich M, Bloor S, Paul A, Noad J, Foeglein A, Matthews SA, Komander D, Bycroft M, Randow F

EMBO J. 2016;35(16):1779–1792. 


TBK1 directs WIPI2 against Salmonella. 

Boyle KB, Thurston TL, Randow F. 

Autophagy. 2016;12(12):2508–2509. 

Boyle KB, Stephens LR, Hawkins PT. Activation of the neutrophil NADPH oxidase by Aspergillus fumigatus. Ann N Y Acad Sci. 2012 Dec;1273:68-73.

Juss JK, Hayhoe RP, Owen CE, Bruce I, Walmsley SR, Cowburn AS, Kulkarni S, Boyle KB, Stephens L, Hawkins PT, Chilvers ER, Condliffe AM. Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival. PLoS One. 2012;7(9):e45933.

Boyle KB, Gyori D, Sindrilaru A, Scharffetter-Kochanek K, Taylor PR, Mócsai A, Stephens LR, Hawkins PT. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011 Mar 1;186(5):2978-89.

Boyle KB, Hadaschik D, Virtue S, Cawthorn WP, Ridley SH, O'Rahilly S, Siddle K. The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation. Cell Death Differ. 2009 May;16(5):782-9.

Anderson KE, Boyle KB, Davidson K, Chessa TA, Kulkarni S, Jarvis GE, Sindrilaru A, Scharffetter-Kochanek K, Rausch O, Stephens LR, Hawkins PT. CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks. Blood. 2008 Dec 15;112(13):5202-11.

Dr Keith  Boyle
Not available for consultancy


Departments and institutes: 
Person keywords: 
immune signalling
cell autonomous immunity