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Cambridge Immunology Network


Innate immunity is critical in recognition and response to pathogens and tumours, including directing the adaptive immune system

After decades of focus on the mechanisms of adaptive immunity, it has become clear that the many diverse systems of innate immunity play critical roles in recognition and response (including directing the adaptive immune system) to pathogens and tumours, as well as being involved in pathogenesis during autoimmunity. Cambridge has a long history in studying various facets of innate immunity, including the discovery of domains shared between the IL1 beta receptors and drosophila Toll genes, which contributed to the discovery of TLR genes in vertebrates. Currently, such work goes on all over Cambridge, involving the departments of Biochemistry, Medicine, Pathology, and Veterinary Medicine as well as Institutes such as Babraham, the MRC-LMB and the CIMR. The work on innate immunity includes structural and functional studies of molecules and their signalling pathways (TLR, NK cell receptor, HSP, AID and APOBEC, and TRIM gene families), genetic and genomic analyses of genes (particularly in the context of autoimmunity and other multigenic diseases), and escape from the components of innate immunity by pathogens (including viruses, bacteria and parasites).

MRC Clinician Scientist Fellow
Dr Camilla  Benfield
Lecturer in Virology, Royal Veterinary College
Dr Barbara  Blacklaws
Senior Lecturer in Molecular Virology
Dr Tammy  Dougan
Cambridge Cardiovascular Research Centres Manager
Dr Emilia Liana Falcone
NIH Cambridge scholar
Dr Brian   Ferguson
University Lecturer
Professor Andres  Floto
Professor of Respiratory Biology
Wellcome Trust Senior Investigator
Dr Nicole  Kaneider
Wellcome Trust Clinical Career Development Fellow
Dr Pietro  Mastroeni
Professor of Infection and Immunity
Dr William  McEwan
Investigator Scientist
Professor Yorgo  Modis
Wellcome Trust Senior Research Fellow
Dr James  Nathan
Wellcome Trust Senior Clinical Fellow
Dr Stefano  Pluchino
University Reader in Regenerative Neuroimmunology
Honorary Consultant in Neurology