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Cambridge Immunology Network

 

Research

My research focuses at developing a complete antagonist(s) of an innate immune receptor. I take advantage of various cell-based approaches to screen a large library of compounds in order to select the most potent and non-cytotoxic ligands. Using structural biology methods, I want to confirm direct interaction between these molecules and receptor. In parallel, direct interactors active in the low concentrations will be chemically modified to improve their antagonistic parameters.

Publications

Key publications: 

β2-Adrenergic receptors in immunity and inflammation: stressing NF-κB.

Kolmus K, Tavernier J, Gerlo S.

Brain Behav Immun. 2015 Mar;45:297-310. doi: 10.1016/j.bbi.2014.10.007. Epub 2014 Oct 22. Review.

 

β-agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms.

Kolmus K, Van Troys M, Van Wesemael K, Ampe C, Haegeman G, Tavernier J, Gerlo S.

PLoS One. 2014 Mar 6;9(6):e90649. doi: 10.1371/journal.pone.0090649. eCollection 2014.

 

Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
β2-adrenergic receptors
TLR4
NF-κB
cytokine and chemokine gene expression