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Dr Alexander von der Malsburg

Research Interests

The key aspects of my research are the identification and the understanding of effector mechanisms of the innate immune system. I am also interested in the molecular basis of cell-autonomous immunity. Currently I am investigating the role of autophagy in the defense against intracellular bacteria.  

Keywords

cell-autonomous immunity ; autophagy

Key Publications

Gao S*, von der Malsburg A*, Dick A, Faelber K, Schröder GF, Haller O, Kochs G, Daumke O. Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function. Immunity. 2011 Oct 28;35(4):514-25.

von der Malsburg A, Abutbul-Ionita I, Haller O, Kochs G, Danino D. Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop. J Biol Chem. 2011 Oct 28;286(43):37858-65.

Daumke O, Gao S, von der Malsburg A, Haller O, Kochs G.Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases. 2010 Jul;1(1):62-64.

Schusser B, Reuter A, von der Malsburg A, Penski N, Weigend S, Kaspers B, Staeheli P, Härtle S.Mx is dispensable for interferon-mediated resistance of chicken cells against influenza A virus. J Virol. 2011 Aug;85(16):8307-15. doi: 10.1128/JVI.00535-11.

Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G.Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity. J Biol Chem. 2010 Sep 10;285(37):28419-24. doi: 10.1074/jbc.R110.145839.

Gao S, von der Malsburg A, Paeschke S, Behlke J, Haller O, Kochs G, Daumke O. Structural basis of oligomerization in the stalk region of dynamin-like MxA. Nature. 2010 May 27;465(7297):502-6. doi: 10.1038/nature08972.