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Professor John Sinclair

Professor John Sinclair

Professor of Molecular Virology


Research Interests

My research interests are in the molecular biology and pathogenesis of human herpes viruses, particularly human cytomegalovirus (HCMV). HCMV is a major cause of disease in transplant patients and patients with AIDS and my research program aims to understand latency and reactivation of this persistent human virus and how the host immune response combats virus disease.

Collaborators

Key Publications

Sinclair J and Reeves M The intimate relationship between human cytomegalovirus and the dendritic cell lineage  Front. Microbiol., 07 August 2014 | doi: 10.3389/fmicb.2014.00389

Mason, GM., Jackson, S., Okecha, G, Poole, E., Sissons, JGP.,  Sinclair, J. and  Wills, MR (2013) Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4+ T cells Plos Path. 2013;9(10)
 
Reeves, M.B. & Sinclair, J.H. (2013) Circulating dendritic cells isolated from healthy seropositive donors are sites of human cytomegalovirus reactivation in vivo. J Virol. In Press
               
Reeves, M. & Sinclair, J. (2013) Regulation of human cytomegalovirus transcription in latency: beyond the major immediate-early promoter. Viruses 5, 1395-1413.
               
Weekes MP, Tan SY, Poole E, Talbot S, Antrobus R, Smith DL, Montag C, Gygi SP, Sinclair JH, Lehner PJ. (2013) Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection. Science 340, 199-202.
               

Poole E, Walther A, Raven K, Benedict CA, Mason GM, Sinclair J. (2013) The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner. J Virol 87, 4261-4271.
               
 Mason, G.M., Poole, E., Sissons, J.G., Wills, M.R. & Sinclair, J.H. (2012) Human cytomegalovirus latency alters the cellular secretome, inducing cluster of differentiation (CD)4+ T-cell migration and suppression of effector function. Proc Natl Acad Sci U S A 109, 14538-14543.