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Dr Felix Randow

Dr Felix Randow

Felix Randow is accepting applications for PhD students.

Felix Randow is available for consultancy.


Office Phone: 01223-412178

Research Interests

We are interested in cell autonomous innate immunity, i.e. in the ability of individual cells to defend themselves against infection.

Cytosolic defence against bacterial invasion
The cytosol is rich in nutrients but very few bacteria can colonize it. We wish to understand how cells deploy the ubiquitin system and autophagy to defend their cytosol.

Regulation of NF-kB and IRF signalling
The defence against pathogens requires profound changes in gene expression, which are coordinated by latent transcription factors of the NF-kB and IRF families. We aim to understand how infection activates NF-kB and IRF signalling.

Somatic cell genetics
The genetic analysis of somatic cell lines holds significant potential to our understanding of signal transduction (and other cell autonomous traits). Through homologous recombination and chemical mutagenesis we have obtained a large collection of gene deficient human and murine cells, with which we address problems of cell autonomous innate immunity.

Keywords

salmonella ; ubiquitin ; autophagy

Key Publications

Beale R, Wise H, Stuart A, Ravenhill BJ, Digard P, Randow F. (2014) A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host Microbe.  15(2):239-47.  

Randow F, MacMicking JD, James LC. (2013) Cellular self-defense: how cell-autonomous immunity protects against pathogens.  Science. 340(6133):701-6

von Muhlinen N, Akutsu M, Ravenhill BJ, Foeglein Á, Bloor S, Rutherford TJ, Freund SM, Komander D, Randow F. (2012)  LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy. Mol Cell. 48(3):329-42. 

Thurston, T.L.M., Wandel, M.P., Muhlinen, Von, N., Foeglein, Á., and Randow, F. (2012). Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.  Nature 482, 414–418.

Bloor S, Maelfait J, Krumbach R, Beyaert R, Randow F. (2010) Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus.  Proc Natl Acad Sci U S A. 107, 6970-5.

Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. (2009) The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol. 10(11):1215-21. 

Randow, F., and Lehner, P. J. (2009). Viral avoidance and exploitation of the ubiquitin system.  Nat Cell Biol 11, 527-534.

invading Salmonella

randowCells defend their cytosol against invading Salmonella by decorating bacteria with ubiquitin and targeting them for autophagy.