skip to content

Cambridge Immunology Network



Supervisor: Martin Turner

I am interested in the post-transcriptional mechanisms that control B-cell development and differentiation. The Turner lab has generated mice which have a B cell-specific deletion of the RNA-binding protein ZFP36l1 (Tis11b), and mice that overexpress a ZFP36l1-GFP fusion protein in B cells. Tis11b (ZFP36l1) is a member of the Tristetraprolin family of RBP, which bind to AU-rich elements in the 3’ untranslated regions of mRNAs.  Tis11b negatively regulates gene expression by destabilising and inhibiting translation of its target mRNAs. Our data show that mice which have a B cell specific deletion of Tis11b lack MZ B cells, and conversely, mice which overexpress a Tis11b-GFP fusion protein in B cells have an expanded MZ B cell compartment. My PhD project is focused on understanding the molecular basis for abnormal MZ B cell development in these genetically-modified mice.

 Rebecca  Newman
Not available for consultancy


Departments and institutes: