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Cambridge Immunology Network



My current research focusses on the role of RNA-binding proteins in lymphocyte development and function


Key publications: 

Salerno F, Engels S, van den Biggelaar M, van Alphen FPJ, Guislain A, Zhao W, Hodge DL, Bell SE, Medema JP, von Lindern M. (2018) Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells. Nat. Immunol. Aug 19(8):828-837


Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M. (2018) The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat. Immunol. Mar 19(3):267-278


Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE & Turner M. (2017) Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat. Immunol.  Jun 18(6):683-693


Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M. (2015) HuR-dependent regulation of mRNA splicing is essential for the B cell antibody response. Nat. Immunol. Apr;16(4):415-25. doi: 10.1038/ni.3115.


Webb LM, Datta P, Bell SE, Kitamura D, Turner M, and Butcher GW (2016) GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo. J. Immunol. 196(1):207-216 doi: 10.4049/jimmunol.1501582


Diaz-Muñoz MD, Bell SE, Turner M. (2015) Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo. PLoS One. 2015 Feb 13;10(2):e0116899. doi: 10.1371/journal.pone.0116899.


Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LMC, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M () Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction.  Journal of Immunology 2010 185 4042-4052


Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews SR, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.  Nature Immunology 2010 11 717-724


Kovesdi D, Bell SE, Turner M The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K.  Self/Nonself 2010 1 144-153


Anouk Caraux, Nayoung Kim, Sarah E. Bell, Simona Zompi, Thomas Ranson, Sarah Lesjean-Pottier, Marcos E, Garcia-Ojeda, Martin Turner, and Francesco Colucci "Phospholipase C-g2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells”, Blood 2006 107(3):994–1002


Sarah E. Bell, Maria Jose Sanchez, Olivera Spasic-Boskovic, Tomas Santalucia, Laure Gambardella, Graham J, Burton, John J, Murphy, John D, Norton Andrew R, Clark & Martin Turner "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression”, Developmental Dynamics 2006 235(11):3144–3155

Not available for consultancy


Collaborator profiles: 
Departments and institutes: 
Person keywords: 
B cell receptor (BCR)
B cells
cell surface molecules
isotype switching
affinity maturation
cell culture
antibody responses
animal models
somatic hypermutation
cell type