Research
My current research focusses on the role of RNA-binding proteins in lymphocyte development and function
Publications
Salerno F, Engels S, van den Biggelaar M, van Alphen FPJ, Guislain A, Zhao W, Hodge DL, Bell SE, Medema JP, von Lindern M. (2018) Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells. Nat. Immunol. Aug 19(8):828-837
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M. (2018) The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers. Nat. Immunol. Mar 19(3):267-278
Newman R, Ahlfors H, Saveliev A, Galloway A, Hodson DJ, Williams R, Besra GS, Cook CN, Cunningham AF, Bell SE & Turner M. (2017) Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat. Immunol. Jun 18(6):683-693
Diaz-Muñoz MD, Bell SE, Fairfax K, Monzon-Casanova E, Cunningham AF, Gonzalez-Porta M, Andrews SR, Bunik VI, Zarnack K, Curk T, Heggermont WA, Heymans S, Gibson GE, Kontoyiannis DL, Ule J, Turner M. (2015) HuR-dependent regulation of mRNA splicing is essential for the B cell antibody response. Nat. Immunol. Apr;16(4):415-25. doi: 10.1038/ni.3115.
Webb LM, Datta P, Bell SE, Kitamura D, Turner M, and Butcher GW (2016) GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo. J. Immunol. 196(1):207-216 doi: 10.4049/jimmunol.1501582
Diaz-Muñoz MD, Bell SE, Turner M. (2015) Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo. PLoS One. 2015 Feb 13;10(2):e0116899. doi: 10.1371/journal.pone.0116899.
Rolf J, Bell SE, Kovesdi D, Janas ML, Soond DR, Webb LMC, Santinelli S, Saunders T, Hebeis B, Killeen N, Okkenhaug K, Turner M () Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. Journal of Immunology 2010 185 4042-4052
Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews SR, Li CM, Pannell R, Siebel CW, MacDonald HR, De Keersmaecker K, Ferrando AA, Grutz G, Turner M Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nature Immunology 2010 11 717-724
Kovesdi D, Bell SE, Turner M The development of mature B lymphocytes requires the combined function of CD19 and the p110δ subunit of PI3K. Self/Nonself 2010 1 144-153
Anouk Caraux, Nayoung Kim, Sarah E. Bell, Simona Zompi, Thomas Ranson, Sarah Lesjean-Pottier, Marcos E, Garcia-Ojeda, Martin Turner, and Francesco Colucci "Phospholipase C-g2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells”, Blood 2006 107(3):994–1002
Sarah E. Bell, Maria Jose Sanchez, Olivera Spasic-Boskovic, Tomas Santalucia, Laure Gambardella, Graham J, Burton, John J, Murphy, John D, Norton Andrew R, Clark & Martin Turner "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression”, Developmental Dynamics 2006 235(11):3144–3155
