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Cambridge Immunology Network



immune escape strategies of contagious cancers such as that causing Tasmanian devil facial cancer epidimic.


Key publications: 

Siddle HV, Kaufman J. Immunology of naturally transmissible tumours.  Immunology. 2015 Jan;144(1):11-20. 

Siddle HV, Kaufman J. How the devil facial tumor disease escapes host immune responses. Oncoimmunology. 2013 Aug 1;2(8)

Siddle HV, Kreiss A, Tovar C, Yuen CK, Cheng Y, Belov K, Swift K, Pearse AM, Hamede R, Jones ME, Skjødt K, Woods GM, Kaufman J. Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer. Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5103-8.

Siddle HV, Kaufman J. A tale of two tumours: Comparison of the immune escape strategies of contagious cancers. Mol Immunol. 2013 Sep;55(2):190-3.

Siddle HV, Deakin JE, Coggill P, Whilming LG, Harrow J, Kaufman J, Beck S, Belov K. The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics. 2011 Aug 19;12:421.

Siddle HV, Marzec J, Cheng Y, Jones M, Belov K. MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer. Proc Biol Sci. 2010 Jul 7;277(1690):2001-6.

Siddle HV, Deakin JE, Coggill P, Hart E, Cheng Y, Wong ES, Harrow J, Beck S, Belov K. MHC-linked and un-linked class I genes in the wallaby. BMC Genomics. 2009 Jul 14;10:310.

Siddle HV, Kreiss A, Eldridge MD, Noonan E, Clarke CJ, Pyecroft S, Woods GM, Belov K. Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16221-6.

Siddle HV, Sanderson C, Belov K. Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii). Immunogenetics. 2007 Sep;59(9):753-60.

Dr Hannah  Siddle
Not available for consultancy


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