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Tu Anh Pham

Research Interests

Supervisor Trevor Lawley

I have a background in molecular biology and clinical medicine and am currently a PhD student at the Wellcome Trust Sanger Institute. My research focuses on understanding the crosstalk between the mucosal immune system and the microbiota, especially during intestinal inflammation. By applying microbiota sequencing and genomic approaches to different knockout mouse models of colitis, I am hoping to uncover components of the microbiota that can directly contribute to disease development. In addition, I will be exploring the therapeutic potential of novel host defense pathways mediated by the intestinal epithelium against bacterial pathogens.

Keywords

epithelial barrier function ; colonisation resistance ; innate immunity ; microbiota

Key Publications

Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity. Dominic Chih-Cheng VOON, Huajing WANG, Jason Kin Wai KOO, Tu Anh Pham N., Yit Teng HOR, Yeh-Shiu CHU, Kosei ITO, Hiroshi FUKAMACHI, Shing Leng CHAN, Jean Paul THIERY and Yoshiaki ITO. Stem Cells 2012 Oct;30(10):2088-99. doi: 10.1002/stem.1183.

Emerging insights on intestinal dysbiosis during bacterial infections. Tu Anh Pham N., Trevor Lawley. Current Opinion in Microbiology, Volume 17, February 2014, Pages 67–74.

Vying over spilt oil. Tu Anh Pham N., Blessing Anonye. Nature Reviews Microbiology (10 February 2014), doi:10.1038/nrmicro3224.

Neutrophils deliver TRAIL-mediated protection from cytomegalovirus infection: An IL-22-driven response. Maria A. Stacey, Morgan Marsden, Tu Anh Pham N., Simon Clare, Garry Dolton, Gabrielle Stack, Emma Jones, Paul Klenerman, Awen M. Gallimore, Philip R. Taylor, Robert J. Snelgrove, Trevor D. Lawley, Gordon Dougan, Simon A. Jones, Gavin W. G. Wilkinson and Ian R. Humphreys. (Manuscript accepted 27 Feb 2014 by Cell Host and Microbe)