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Dr Xi Chen

Research Interests

Transcriptional regulatory networks control cell fate decisions and cell cycle progression, both of which are key processes in the T helper cell compartment. T helper cells differentiate from a naïve resting state into a specific and proliferative state when they are presented with antigens. Transcription factors are the driving forces during this differentiation process. I am interested in utilising genomic technologies (ChIP-seq, RNA-seq etc.) to investigate how TFs control the T helper cell differentiation.

Keywords

genomics ; ChIP ; Th2 ; cell differentiation ; cell fate decision ; bioinformatics ; transcriptional regulatory networks ; gene regulation

Collaborators

Key Publications

Chen X, Müller GA, Quaas M, Fischer M, Han N, Stutchbury B, Sharrocks AD, Engeland K. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol Cell Biol. 2013 Jan;33(2):227-36