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Cambridge Immunology Network



We use advanced bacterial genomics and metagenomics to better understand the evolution and spread of pathogens locally, nationally and globally. Realising the complexity of big data and its limited understanding in most developing and underdeveloped countries, we mine genomic data for robust, risk-informative diagnostic markers. My group uses these markers to design smart detection probes in field compatible format. This technology driven global health approach makes my research accessible to the communities who need it most.


Key publications: 


Mutreja A, Dougan G. Molecular epidemiology and intercontinental spread of cholera. Vaccine. 2020 Feb 29;38:A46-51.


Houldcroft CJ, Beale MA, Sayeed MA, Qadri F, Dougan G, Mutreja A. Identification of novel adenovirus genotype 90 in children from Bangladesh. Microbial genomics. 2018 Oct;4(10).


Domman D, Chowdhury F, Khan AI, Dorman MJ, Mutreja A, Uddin MI, Paul A, Begum YA, Charles RC, Calderwood SB, Bhuiyan TR. Defining endemic cholera at three levels of spatiotemporal resolution within Bangladesh. Nature genetics. 2018 Jul;50(7):951-5.


Domman D, Quilici ML, Dorman MJ, Njamkepo E, Mutreja A, Mather AE, Delgado G, Morales-Espinosa R, Grimont PA, Lizárraga-Partida ML, Bouchier C. Integrated view of Vibrio cholerae in the Americas. Science. 2017 Nov 10;358(6364):789-93.


Weill FX … Mutreja A … Thomson NR. Genomic history of the seventh pandemic of cholera in Africa. Science. 2017 Nov 10;358(6364):785-9.


Karlsson SL, Thomson N, Mutreja A, Connor T, Sur D, Ali M, Clemens J, Dougan G, Holmgren J, Lebens M. Retrospective analysis of serotype switching of Vibrio cholerae O1 in a cholera endemic region shows it is a non-random process. PLoS neglected tropical diseases. 2016 Oct;10(10).


Mutreja A, Kim DW, Thomson NR, Connor TR, Lee JH, Kariuki S, Croucher NJ, Choi SY, Harris SR, Lebens M, Niyogi SK. Evidence for several waves of global transmission in the seventh cholera pandemic. Nature. 2011 Sep;477(7365):462-5.

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