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Cambridge Immunology Network



Dr Edward Banham-Hall is a consultant physician at Addenbrookes Hospital who holds a PhD from Cambridge University having successfully defended his thesis on the subject of the role of the p110delta isoform of PI3 kinase in immune responses to Streptococcus pneumoniae.  During his research he took a leading role in the discovery of a novel cause of Primary Immunodeficiency called Activated PI3kinase Delta Syndrome, or APDS.


He now works as a Principal Investigator for several early phase clinical trials, including a clinical trial investigating a possible novel treatment for patients with APDS. He is seconded to GSK for part of his time, where he undertakes experimental medicine studies in healthy volunteers and patients.


In his spare time Dr Banham-Hall works on projects that combine digital breakthroughs with clinical and biological opportunities.  His latest project in this respect is the technical development of an educational website for postgraduate medical training, Clinical Skills Pro.


Key publications: 


1.      Pritchard RH, Zhukov AA, Fullerton JN, Want AJ, Hussain F, la Cour MF, Bashtanov ME, Gold RD, Hailes A, Banham-Hall E, Rogers SS. Cell sorting actuated by a microfluidic inertial vortex. Lab Chip. 2019 Jul 9;19(14):2456-2465. doi: 10.1039/c9lc00120d. PubMed PMID: 31210196.



2.      Wilson R, Templeton A, Leemereise C, Eames R, Banham-Hall E, Hessel EM, Cahn A. Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals. Clin Ther. 2019 Jun;41(6):1214-1220. doi: 10.1016/j.clinthera.2019.04.008. Epub 2019 May 7. PubMed PMID: 31076203.



3.      Banham-Hall E, Stevens S. Hindsight bias critically impacts on clinicians' assessment of care quality in retrospective case note review. Clin Med (Lond). 2019 Jan;19(1):16-21. doi: 10.7861/clinmedicine.19-1-16. PubMed PMID: 30651239; PubMed Central PMCID: PMC6399623.



4.      Stark AK, Chandra A, Chakraborty K, Alam R, Carbonaro V, Clark J, Sriskantharajah S, Bradley G, Richter AG, Banham-Hall E, Clatworthy MR, Nejentsev S, Hamblin JN, Hessel EM, Condliffe AM, Okkenhaug K. PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumonia infection in an antibody-independent manner. Nat Commun. 2018 Aug 9;9(1):3174. doi: 10.1038/s41467-018-05674-8. PubMed PMID: 30093657; PubMed Central PMCID: PMC6085315.



5.      Banham-Hall E, Jeffrey M, Cameron E, Burton T, Fry A. Reviewing post-discharge mortality improves morbidity and mortality processes for patients with a general medical hospital admission. Clin Med (Lond). 2016 Oct;16(5):495. Review. PubMed PMID: 27697820; PubMed Central PMCID: PMC6297293.



6.      Angulo I, Vadas O, Garçon F, Banham-Hall E, Plagnol V, Leahy TR, Baxendale H, Coulter T, Curtis J, Wu C, Blake-Palmer K, Perisic O, Smyth D, Maes M, Fiddler C, Juss J, Cilliers D, Markelj G, Chandra A, Farmer G, Kielkowska A, Clark J, Kracker S, Debré M, Picard C, Pellier I, Jabado N, Morris JA, Barcenas-Morales G, Fischer A, Stephens L, Hawkins P, Barrett JC, Abinun M, Clatworthy M, Durandy A,  Doffinger R, Chilvers ER, Cant AJ, Kumararatne D, Okkenhaug K, Williams RL, Condliffe A, Nejentsev S. Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage. Science. 2013 Nov 15;342(6160):866-71. doi: 10.1126/science.1243292. Epub 2013 Oct 17. PubMed PMID: 24136356; PubMed Central PMCID: PMC3930011.



7.      Banham-Hall E, Clatworthy MR, Okkenhaug K. The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases. Open Rheumatol J. 2012;6:245-58. doi: 10.2174/1874312901206010245. Epub 2012 Sep 7. PubMed PMID: 23028409; PubMed  Central PMCID: PMC3460535.



8.      Maund I, Banham-Hall E, Mallinson R. Local thrombolytic therapy for primary axillosubclavian vein thrombosis. JRSM Short Rep. 2010 Jun 30;1(1):9. doi: 10.1258/shorts.2009.090393. PubMed PMID: 21103101; PubMed Central PMCID: PMC2984334.



9.      Deveson P, Goodyear H, Savage W, Bolsin S, Polnay L, Cass H; 228 other doctors. Support for child-protection whistleblower Kim Holt. Lancet. 2010 Apr 17;375(9723):1343. doi: 10.1016/S0140-6736(10)60567-3. Erratum in: Lancet. 2010 Jul 17;376(9736):162. PubMed PMID: 20399974.



10.   Banham-Hall EJ, Bokhari AM. Malignancy with unknown primary presenting as acute cardiac tamponade: a case report. Cases J. 2009 Jun 18;2:8176. doi: 10.4076/1757-1626-2-8176. PubMed PMID: 19830059; PubMed Central PMCID: PMC2740000.



11.   Banham-Hall E, Mallinson R, Trepte N. Poisoning and toxicological emergencies - current trends and practice. Acute Med. 2009;8(1):17-21. PubMed PMID: 21607204.


Dr Edward  Banham-Hall
Not available for consultancy


Person keywords: 
PI3K regulation