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Dr Alexandre Bignon

Research Interests

Alexandre Bignon was awarded Ph.D. in immunology from Paris-Sud 11 University in September 2014. His PhD works focused on the expression and function of chemokine receptors in two immune disorders, namely CCR1 in the lupus-prone NZB/W mouse model and CXCR4 in the Idiopathic CD4+ T-cell lymphopenia, a rare human immune defect. This research was performed in the group of Dr Karl Balabanian at the INSERM unit UMR_S 996 (Clamart, France). He joined Michelle Linterman’s group as a postdoctoral scientist in the Dept. of Lymphocyte Signalling Lab and Development, Babraham Institute, Cambridge, UK in November 2014. His current interest is to determine the role of Heat-Labile Enterotoxin, B subunit from E. coli on autoimmunity and vaccine efficacy in collaboration with Trident Pharmaceuticals. The aim of this project is to generate mechanistic insight into how a mucosal therapeutic modifies both helper and regulatory T cell biology.

Keywords

FOXP3 ; senescence ; germinal center ; T cells ; regulatory T cells ; chemokines

Topics

  • influenza
  • autoimmunity

Key Publications

Barrientos L, Bignon A, Gueguen C, de Chaisemartin L, Gorges R, Sandré C, Mascarell L, Balabanian K, Kerdine-Römer S, Pallardy M, Marin-Esteban V, Chollet-Martin S. Neutrophil Extracellular Traps Downregulate Lipopolysaccharide-Induced Activation of Monocyte-Derived Dendritic Cells. J Immunol. 2014 Dec 1;193(11):5689-5698. Epub 2014 Oct 22.

Boujedidi H, Robert O, Bignon A, Cassard-Doulcier AM, Renoud ML, Gary-Gouy H, Hemon P, Tharinger H, Prévot S, Bachelerie F, Naveau S, Emilie D, Balabanian K, Perlemuter G. CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients. Clin Sci (Lond). 2015 Feb 1;128(4):257-67. doi: 10.1042/CS20130833.

Bignon A, Gaudin F, Hémon P, Tharinger H, Mayol K, Walzer T, Loetscher P, Peuchmaur M, Berrebi D, Balabanian K. CCR1 inhibition ameliorates the progression of lupus nephritis in NZB/W mice. J Immunol. 2014 Feb 1;192(3):886-96. doi: 10.4049/jimmunol.1300123. Epub 2013 Dec 23.

Biajoux V*, Bignon A*, Freitas C, Martinez V, Thelen M, Lima G, Jakez-Ocampo J, Emilie D, Llorente L, Balabanian K. Expression of CXCL12 receptors in B cells from Mexican Mestizos patients with systemic Lupus erythematosus. J Transl Med. 2012 Dec 18;10:251. doi: 10.1186/1479-5876-10-251

Humpert ML, Tzouros M, Thelen S, Bignon A, Levoye A, Arenzana-Seisdedos F, Balabanian K, Bachelerie F, Langen H, Thelen M. Complementary methods provide evidence for the expression of CXCR7 on human B cells. Proteomics. 2012 Jun;12(12):1938-48. doi: 10.1002/pmic.201100581.

Bignon A, Biajoux V, Bouchet-Delbos L, Emilie D, Lortholary O, Balabanian K. CXCR4, a therapeutic target in rare immunodeficiencies? Med Sci (Paris). 2011 Apr;27(4):391-7. doi: 10.1051/medsci/2011274015. Epub 2011 Apr 28. Review. French.