Research
- P. falciparum merozoite:Red blood cell - A host-pathogen interaction required for the pathogenesis of malaria.
- Platelet:Platelet - The cellular interaction responsible for heart disease and stroke, two of the leading causes of human mortality.
- Sperm:Egg - The cellular interaction responsible for new life. Understanding this could lead to the development of novel contraceptives and fertility treatments.
Publications
Bianchi-E, Doe-B, Goulding-D, Wright-GJ. “Juno is the Izumo egg receptor and is essential for mammalian fertilization.” Nature 2014 508 p483.
Bianchi-E and Wright-GJ. “Cross-species fertilisation: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1.” Philosophical Transactions B 2015 370 p20140101.
Crosnier-C, Bustamante-LY, Bartholdson-SJ, Bei-AK, Theron-M, Uchikawa-M, Mboup-S, Ndir-O, Kwiatkowski-DP, Duraisingh-MT, Rayner-JC, Wright-GJ. “Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.” Nature 2011 480 p534.
Wanaguru-M, Liu-W, Hahn-BH, Rayner-JC, Wright-GJ. “The RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.” PNAS 2013 110 p20735.
Zenonos-ZA, Dummler-SK, Muller-Sienerth-N, Chen-J, Preiser-PR, Rayner-JC, Wright-GJ. “Basigin is a druggable target for host-oriented anti-malarial interventions.” Journal of Experimental Medicine 2015 212 p1145.
Galaway-F, Drought-LG, Fala-M, Cross-N, Kemp-AC, Rayner-JC, Wright-GJ. “P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5.” Nature Communications 2017 8 p14333.
Douglas-AD, Baldeviano-GC, Lucas-CM, Lugo-Roman-LA, Crosnier-C, Bartholdson-SJ, Diouf-A, Miura-K, Lambert-LE, Ventocilla-JA, Leiva-KP, Milne-KH, Illingworth-JJ, Spencer-AJ, Hjerrild-KA, Alanine-DG, Turner-AV, Moorhead-JT, Edgel-KA, Wu-Y, Long-CA, Wright-GJ, Lescano-AG, Draper-SJ. “A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in Aotus monkeys.” Cell Host Microbe 2015 14 p130.
Bartholdson-SJ, Bustamante-LY, Crosnier-C, Johnson-S, Lea-S, Rayner-JC, Wright-GJ. "Semaphorin-7A is an Erythrocyte Receptor for P. falciparum Merozoite-Specific TRAP Homolog, MTRAP." PLoS Pathogens 2012 8 e1003031.
Crosnier-C, Wanaguru-M, McDade-B, Osier-FH, Marsh-K, Rayner-JC, Wright-GJ. “A library of functional recombinant cell-surface and secreted P. falciparum merozoite proteins.” Molecular and Cellular Proteomics 2013 12 p3976.
Crosnier-C, Iqbal-Z, Knuepfer-E, Maciuca-S, Perrin-AJ, Kamuyu-G, Goulding-D, Bustamante-LY, Miles-A, Moore-SC, Dougan-G, Holder-AA, Kwiatkowski-DP, Rayner-JC, Pleass-RJ, Wright-GJ. "Binding of Plasmodium falciparum merozoite surface proteins DBLMSP and DBLMSP2 to human Immunoglobulin M is conserved among broadly diverged sequence variants." Journal of Biological Chemistry 2016 291 p14285.
Wanaguru-M, Crosnier-C, Johnson-S, Rayner-JC, Wright-GJ. “A biochemical analysis of the Plasmodium falciparum Erythrocyte Binding Antigen-175 (EBA175): Glycophorin-A interaction: implications for vaccine design.” Journal of Biological Chemistry 2013 288 p32106.
Dundas-K, Shears-MJ, Sun-Y, Hopp-CS, Crosnier-C, Metcalf-T, Girling-G, Sinnis-P, Billker-O, Wright-GJ. “Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.” PNAS 2018 115 p4477.
Wright-GJ, Puklavec-MJ, Willis-AC, Hoek-RM, Sedgwick-JD, Brown-MH and Barclay-AN. “Lymphoid/neuronal cell surface OX2 glycoprotein recognises a novel receptor on macrophages implicated in the control of their function.” Immunity. 13 2000 p233.
Hoek-RM, Ruuls-SR, Murphy-CA, Wright-GJ, Goddard-R, Zurawski-SM, Blom-B, Homola-ME, Streit-WJ, Brown-MH, Barclay-AN, Sedgwick-JD. “Down-regulation of the macrophage lineage through interaction with OX2 (CD200).” Science. 290 2000 p1768.
Powell-GT and Wright-GJ. “Jamb and jamc are essential for vertebrate myocyte fusion.” PLoS Biology 2011 9 e1001216.
Söllner-C and Wright-GJ. “A cell surface interaction network of neural leucine-rich repeat receptors.” Genome Biology 2009 10 R99.
Wright-GJ†, Leslie-JD†, Ariza-McNaughton-L and Lewis-J. “Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.” Development 131 2004 p5659.
Bushell-KM, Söllner-C, Schuster-Boeckler-B, Bateman-A, Wright-GJ. “Large-scale screening for novel low-affinity extracellular protein interactions.” Genome Research 2008 18 p622.
Sharma-S, Bartholdson-SJ, Couch-A, Yusa-K, Wright-GJ. “Genome-scale identification of cellular pathways required for cell surface recognition.” Genome Research 2018 28 p1372.
Sun-Y, Vandenbriele-C, Kauskot-A, Verhamme-P, Hoylaerts-MF, Wright-GJ. “A human platelet receptor protein microarray identifies FcεR1α as an activating PEAR1 ligand.” Molecular and Cellular Proteomics 2015 14 p1265.
