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Lucy Hepburn

Research Interests

I am interested in understanding how innate immune responses are regulated during Staphylococcus aureus infection and how they might be manipulated therapeutically

Keywords

cytokine secretion ; phagocytosis ; intracellular killing ; host innate immunity ; macrophages ; calcium signalling ; human studies ; autophagy ; chemotaxis ; confocal microscopy ; FACS ; ELISA's ; neutrophils

Topics

  • Staphylococcus aureus

Key Publications

Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón‐Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein, Rodrigo Andres Floto Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion EMBO Molecular Medicine

Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Török ME, Peacock SJ, Holden M, Blundell T, Wang L, Ligoxygakis P, Minichiello L, Woods CG, Foster SJ, Renshaw SA, Floto RA. Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus. Science. 2014 Oct 31;346(6209):641-6.