University Reader; Honorary Transplant Consultant
Research
Biography/Research interests
Mr Kourosh Saeb-Parsy joined the Department of Surgery in 2007 as a Clinical Lecturer and was appointed as University Lecturer and Honorary Consultant Transplant Surgeon in 2012. He was appointed as Reader in Transplantation in 2018. He has also been a Fellow and Director of Studies in Clinical Medicine at Fitzwilliam College since 2003.
His laboratory research interests are focused on the cellular and humoral immune response to transplantation, the impact of ischaemia reperfusion injury on acute and chronic graft function, and the immunogenicity of stem cells and their derivatives. His clinical research is directed towards identification of donor and recipient factors that can affect graft and patient outcomes after kidney, pancreas and liver transplantation.
His collaborative, multidisciplinary and translational research program is focused on:
- Function and immunogenicity of transplanted regenerative cellular therapies
- Ischaemia-reperfusion injury in transplantation
- Translational research using human tissue
- Clinical outcomes after transplantation
Website: Saeb-Parsy Lab
Publications
Coorens THH, Treger TD, Al-Saadi R, Moore L, Tran MGB, Mitchell TJ, Tugnait S, Thevanesan C, Young MD, Oliver TRW, Oostveen M, Collord G, Tarpey PS, Cagan A, Hooks Y, Brougham M, Reynolds BC, Barone G, Anderson J, Jorgensen M, Burke GAA, Visser J, Nicholson JC, Smeulders N, Mushtaq I, Stewart GD, Campbell PJ, Wedge DC, Martincorena I, Rampling D, Hook L, Warren AY, Coleman N, Chowdhury T, Sebire N, Drost J, Saeb-Parsy K, Stratton MR, Straathof K, Pritchard-Jones K, Behjati S. (2019) Embryonal precursors of Wilms tumor. Science. 2019 Dec 6;366(6470):1247-1251
Martin JL, Costa ASH, Gruszczyk AV, Beach TE, Allen FM, Prag HA, Hinchy EC, Mahbubani K, Hamed M, Tronci L, Nikitopoulou E, James AM, Krieg T, Robinson AJ, Huang MM, Caldwell ST, Logan A, Pala L, Hartley RC, Frezza C, Saeb-Parsy K*, Murphy MP* (2019) Succinate accumulation drives ischaemia reperfusion injury during organ transplantation. Nature Metabolism 1;966-974. * Equal contribution
Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA, Moore L, Georgakopoulos N, Torrente F, Noorani A, Goddard M, Robinson P, Coorens THH, O'Neill L, Alder C, Wang J, Fitzgerald RC, Zilbauer M, Coleman N, Saeb-Parsy K, Martincorena I, Campbell PJ, Stratton MR (2019) The landscape of somatic mutation in normal colorectal epithelial cells. Nature. 574(7779):532-537.
Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA (2019). A cellular census of human lungs identifies novel cell states in health and in asthma. Nature Medicine. Jul;25(7):1153-1163.
Tysoe OC , Justin AW , Brevini T , Chen SE , Mahbubani KT , Frank AK , Zedira H , Melum E , Saeb-Parsy K*, Markaki* AE , Vallier E*, Sampaziotis F* (2019). Isolation and propagation of primary human cholangiocyte organoids for the generation of bio-engineered biliary tissue. Nature Protocols 14(6):1884-1925. * Equal contribution.
Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F, Hall MWJ, Cagan A, Murai K, Mahbubani K, Stratton MR, Fitzgerald RC, Handford PA, Campbell PJ, Saeb-Parsy K, Jones PH (2018). Somatic mutant clones colonize the human esophagus with age. Science 362(6417):911-917.
Broutier L, Mastrogiovanni G, Verstegen GMA, Francies HE, Morrill E, Bradshaw CR, Allen GE, Arnes R, Gaspersz MP, Georgakopoulos N, Koo B-K, Dietman S, Davies SE, Praseedom R, de Jonge J, IJzermans JNM, Wigmore SJ, Saeb-Parsy K, Garnett MJ, van der Laan LJW, Huch M (2017). Tumour-derived Organoid Cultures model Primary Human Liver Cancer in vitro. Nature Medicine 23(12):1424-1435.
Sampaziotis F, Justin AW, Tysoe OC, Sawiak S, Godfrey EM, Upponi SS, Gieseck RL, de Brito MC, Berntsen NL, Gómez-Vázquez MJ, Ortmann D, Yiangou L, Ross A, Bargehr J, Bertero A, Zonneveld MCF, Pedersen MT, Pawlowski M, Valestrand L, Madrigal P, Georgakopoulos N, Pirmadjid N, Skeldon GM, Casey J, Shu W, Materek PM, Snijders KE, Brown SE, Rimland CA, Simonic I, Davies SE, Jensen KB, Zilbauer M, Gelson WTH, Alexander A, Sinha S, Hannan NRF, Wynn TA, Karlsen TH, MelumE, Markaki AE, Saeb-Parsy K*, Vallier L* (2017). Reconstruction of the murine extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23(8):954-963 (* equal contribution).
Dyson M, Watson CJ, Liddell K, Padfield N, Bradley JA, Saeb-Parsy K (2015) Transplanting suboptimum organs: medico-legal implications. Lancet 386: 719-21.
Chouchani ET, Pell VR, Gaude E, Aksentijevic´ D, Sundier SY, Robb EL, Logan A, Nadtochiy AM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu C-H, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431-5.
A full list of publications is available here.
