Immunology
Natural Killer Cells (NK cells)
Killer Ig-like Receptors (KIRs)
Human Cytomegalovirus
Cambridge Immunology Network
One focus of our lab is to study the interaction of Natural Killer (NK) cell receptors with different MHC class I molecules. NK cells are regulated by a large repertoire of germline-encoded inhibitory and activating receptors. The function of most inhibitory receptors is well-defined. Inhibitory Killer Immunoglobin-like receptors (KIRs; KIR2DL1-3, KIR2DL5, KIR3DL1-3) are inhibitory receptors that recognize certain allotypes of HLA class I. However, the specific ligand and consequently the function of activating receptors remain mostly unknown, in particular activating KIRs (KIR2DS1-5, KIR3DS1). The aim of my project is to search for activating KIR ligands and subsequently investigate their functions.
Cambridge Immunology Network Coordinator
University of Cambridge Department of Medicine,
Jeffrey Cheah Biomedical Centre,
Cambridge Biomedical Campus, Puddicombe Way,
Cambridge, CB2 0AW
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