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Cambridge Immunology Network



My main interest is the immunology of sterile inflammation

Initially I worked on the interactions between infections and auto immune type 1 diabetes (the so called hygiene hypothesis) where I demonstrated how Salmonella typhimurium infection protects against diabetes development in the NOD mouse. I also helped to characterise the first NOD es cells to be successfully generated which could produce viable fertile mice, developing new tools for studying this disease.

Now I have since moved into the field of cardiovascular medicine. Here I am interested in how a very rare immune cell (type II innate lymphoid cells) can influence the progression and development of atherosclerosis as well as during wound healing after myocardial infarction


Key publications: 

Impaired Autophagy in CD11b+ Dendritic Cells Expands CD4+ Regulatory T Cells and Limits Atherosclerosis in Mice.

Clement M, Raffort J, Lareyre F, Tsiantoulas D, Newland S, Lu Y, Masters L, Harrison J, Saveljeva S, Ma MKL, Ozsvar-Kozma M, Lam BYH, Yeo GSH, Binder CJ, Kaser A, Mallat Z.

Circ Res. 2019 Nov 8;125(11):1019-1034. doi: 10.1161/CIRCRESAHA.119.315248. Epub 2019 Oct 15.


MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.

Clement M, Chen X, Chenoweth HL, Teng Z, Thome S, Newland SA, Harrison J, Yu X, Finigan AJ, Mallat Z, Li X.

Arterioscler Thromb Vasc Biol. 2019 Aug;39(8):1645-1651. doi: 10.1161/ATVBAHA.119.312478. Epub 2019 Jun 6.


Deletion of IRF8 (Interferon Regulatory Factor 8)-Dependent Dendritic Cells Abrogates Proatherogenic Adaptive Immunity.

Clément M, Haddad Y, Raffort J, Lareyre F, Newland SA, Master L, Harrison J, Ozsvar-Kozma M, Bruneval P, Binder CJ, Taleb S, Mallat Z.

Circ Res. 2018 Mar 16;122(6):813-820. doi: 10.1161/CIRCRESAHA.118.312713. Epub 2018 Feb 7.


X-Box Binding Protein-1 Dependent Plasma Cell Responses Limit the Development of Atherosclerosis.

Sage AP, Nus M, Bagchi Chakraborty J, Tsiantoulas D, Newland SA, Finigan AJ, Masters L, Binder CJ, Mallat Z.

Circ Res. 2017 Jul 21;121(3):270-281. doi: 10.1161/CIRCRESAHA.117.310884. Epub 2017 Jun 15.


Type-2 innate lymphoid cells control the development of atherosclerosis in mice.

Newland SA, Mohanta S, Clément M, Taleb S, Walker JA, Nus M, Sage AP, Yin C, Hu D, Kitt LL, Finigan AJ, Rodewald HR, Binder CJ, McKenzie ANJ, Habenicht AJ, Mallat Z. Nat Commun. 2017 Jun 7;8:15781. doi: 10.1038/ncomms15781.


Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet.

Nus M, Sage AP, Lu Y, Masters L, Lam BYH, Newland S, Weller S, Tsiantoulas D, Raffort J, Marcus D, Finigan A, Kitt L, Figg N, Schirmbeck R, Kneilling M, Yeo GSH, Binder CJ, de la Pompa JL, Mallat Z. Nat Med. 2017 May;23(5):601-610. doi: 10.1038/nm.4315. Epub 2017 Apr 17.


The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1β secretion in macrophages.

Ferguson BJ, Newland SA, Gibbs SE, Tourlomousis P, Fernandes dos Santos P, Patel MN, Hall SW, Walczak H, Schramm G, Haas H, Dunne DW, Cooke A, Zaccone P.

Int J Parasitol. 2015 Nov;45(13):809-13. doi: 10.1016/j.ijpara.2015.08.005. Epub 2015 Sep 16.

Morgan MA, Muller PS, Mould A, Newland SA, Nichols J, Robertson EJ, Cooke A, Bikoff EK. The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice. PLoS One. 2013;8(2):e56738. doi:

Newland SA, Phillips JM, Mastroeni P, Azuma M, Zaccone P, Cooke A. PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: no role for Tregs. Eur J Immunol. 2011 Oct;41(10):2966-76.

Bending D, Newland S, Krejcí A, Phillips JM, Bray S, Cooke A. Epigenetic changes at Il12rb2 and Tbx21 in relation to plasticity behavior of Th17 cells. J Immunol. 2011 Mar 15;186(6):3373-82.

Nichols J, Jones K, Phillips JM, Newland SA, Roode M, Mansfield W, Smith A, Cooke A. Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat Med. 2009 Jul;15(7):814-8.

Willcocks LC, Lyons PA, Clatworthy MR, Robinson JI, Yang W, Newland SA, Plagnol V, McGovern NN, Condliffe AM, Chilvers ER, Adu D, Jolly EC, Watts R, Lau YL, Morgan AW, Nash G, Smith KG. Copy number of FCGR3B, which is associated with systemic lupus erythematosus, correlates with protein expression and immune complex uptake. J Exp Med. 2008 Jul 7;205(7):1573-82.

Newland SA, Macaulay IC, Floto AR, de Vet EC, Ouwehand WH, Watkins NA, Lyons PA, Campbell DR. The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro. Blood. 2007 109(11):4806-9.

de Vet EC, Newland SA, Lyons PA, Aguado B, Campbell RD. The cell surface receptor G6b, a member of the immunoglobulin superfamily, binds heparin. FEBS Lett. 2005 Apr 25;579(11):2355-8.

Not available for consultancy