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Professor Susan Ozanne

Professor Susan Ozanne

Susan Ozanne is accepting applications for PhD students.

Research Interests

Nutritional programming of health across the life course.

It is well establish that growth and nutrition during fetal and neonatal life can have a long-term effect on an individual’s health-span and lifespan. Initial focus was directed towards the importance of diet during critical periods of development on metabolic health including risk of type 2 diabetes, obesity and cardiovascular disease. However more recent evidence from humans and animal models have revealed that such “nutritional programming” can also influence non-metabolic factors such as our immune health. Our recent findings have demonstrated that maternal diet and early growth patterns can influence ageing of the immune system including effects on thymic growth and involution. These effects may contribute to the programming effects of maternal diet on offspring lifespan.

Key Publications

Alfaradhi MZ, Fernandez-Twinn DS, Martin-Gronert MS, Musial B, Fowden AL & Ozanne SE (2014) Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity Am. J. Physiol. 307:R26-34 

Carr SK, Chen J-H. Cooper W, Constancia M, Yeo G & Ozanne SE (2014) Maternal diet amplifies the hepatic aging trajectory of CIDEA in male mice and leads to development of fatty liver. FASEB J 28: 2191-201

Tarry-Adkins JL, Martin-Gronert MA, Fernandez-Twinn DS, Hargreaves I, Alfaradhi MA, Land JM, Aiken CE & Ozanne SE (2013) Poor maternal nutrition followed by accelerated postnatal growth leads to  alterations in DNA damage and repair, oxidative and nitrosative stress and oxidative defense capacity in rat heart. FASEB J 27:379-90

Blackmore HL, Piekarz AV, Fernandez-Twinn DS, Mercer JR, Figg N, Bennett M & Ozanne SE (2012) Poor maternal nutrition programs a pro-atherosclerotic phenotype in ApoE-/- mice Clinical Science 123: 251-7

Chen JH, Tarry-Adkins JL, Heppolette CA, Palmer DB & Ozanne SE (2010) Early life nutrition influences thymic growth in male mice that may be related to the regulation of longevity. Clinical Science 118: 429-38

Ozanne SE & Hales C.N (2004) Lifespan: catch-up growth and obesity in male mice. Nature: 427: 411-412