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Cambridge Immunology Network

 

Research

Analysis of the implication of ARE binding proteins (AREBPs) in B cell proliferation and plasma cell differentiation through the generation of conditional knock out mice.

Publications

Key publications: 

Díaz-Muñoz MD, Osma-García IC, Iñiguez MA, Fresno M. Cyclooxygenase-2 deficiency in macrophages leads to defective p110γ PI3K signaling and impairs cell adhesion and migration. J Immunol. 2013 Jul 1;191(1):395-406. 

Díaz-Muñoz MD, Osma-García IC, Fresno M, Iñiguez MA. Involvement of PGE2 and the cAMP signalling pathway in the up-regulation of COX-2 and mPGES-1 expression in LPS-activated macrophages. Biochem J. 2012 Apr 15;443(2):451-61.

Iñiguez MA, Punzón C, Cacheiro-Llaguno C, Díaz-Muñoz MD, Duque J, Cuberes R, Alvarez I, Andrés EM, Buxens J, Buschmann H, Vela JM, Fresno M. Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors. Int Immunopharmacol. 2010 Oct;10(10):1295-304.

Díaz-Muñoz MD, Osma-García IC, Cacheiro-Llaguno C, Fresno M, Iñiguez MA. Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages. Cell Signal. 2010 Oct;22(10):1427-36.

Santos J, González-Sánchez L, Matabuena-Deyzaguirre M, Villa-Morales M, Cozar P, López-Nieva P, Fernández-Navarro P, Fresno M, Díaz-Muñoz MD, Guenet JL, Montagutelli X, Fernández-Piqueras J. A role for stroma-derived annexin A1 as mediator in the control of genetic susceptibility to T-cell lymphoblastic malignancies through prostaglandin E2 secretion. Cancer Res. 2009 Mar 15;69(6):2577-87.

Vila-del Sol V, Díaz-Muñoz MD, Fresno M, Requirement of tumor necrosis factor alpha and nuclear factor-kappaB in the induction by IFN-gamma of inducible nitric oxide synthase in macrophages. J Leukoc Biol. 2007 Jan;81(1):272–83.

Duque J, Díaz-Muñoz MD, Fresno M, Iñiguez MA, Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. Cell Signal, 2006 Aug;18(8):1262 9:

Dr Manuel D Díaz-Muñoz
Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
signal transduction
B cells
protein purification
microscopy
confocal microscopy
differentiation
interleukin
cytokines
memory cells
B cell receptor (BCR)
adhesion molecules
germinal center
inflammation
RNA IP
monocytes
iCLIP
RNA and DNA FISH
immunohistochemistry
AREBP
macrophages
polysome fractionation
activation
affinity maturation
animal models
traffic
recombinant protein expression
immune response
eicosanoids
circulation
statistical analysis
isotype switching
inflammatory mediators
cell culture
cell development
fluorescence microscopy
somatic hypermutation
FACS
signalling
dendritic cells
migration