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Cambridge Immunology Network

 

Research

I am curently interested in chicken MHC, and potential vaccination strategies in chickens.

Publications

Key publications: 

Lomonosov M, Meziane el K, Ye H, Nelson DE, Randle SJ, Laman H. Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis. PLoS One. 2011;6(6):e21165. Epub 2011 Jun 17.

Meziane el K, Randle SJ, Nelson DE, Lomonosov M, Laman H. Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86

Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J Biol Chem. 2008 Aug 8;283(32):22325-35.

Meziane el K, Bhattacharyya T, Armstrong AC, Qian C, Hawkins RE, Stern PL, Dermime S. Use of adenoviruses encoding CD40L or IL-2 against B cell lymphoma. Int J Cancer. 2004 Oct 10;111(6):910-20.

Dermime S, Gilham DE, Shaw DM, Davidson EJ, Meziane el-K, Armstrong A, Hawkins RE, Stern PL. Vaccine and antibody-directed T cell tumour immunotherapy. Biochim Biophys Acta. 2004 Jul 6;1704(1):11-35.

Not available for consultancy

Affiliations

Classifications: 
Departments and institutes: 
Person keywords: 
co-stimulation
B cells
co-stimulatory molecules
anergy
natural killer cells
cytokine/interleukin/chemokine receptors
interleukin
cytokines
B cell receptor (BCR)
T cell receptor (TCR)
tolerance
cytotoxic T cells (CTL)
apoptosis
activation
T cells
human studies
antibody responses
animal models
suppression
natural killer receptors
cytotoxicity
lectins
cell development
stem cells