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Dr Emilia Liana Falcone

Research Interests

Supervisors: Professor Clare Bryant and Dr. Steven Holland (NIH/NIAID)

Chronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by recurrent infections and inflammatory complications as a result of reduced phagocyte-mediated production of reactive oxygen species (ROS).  The most common inflammatory complication in CGD is inflammatory bowel disease (IBD), affecting almost 50% of patients, making CGD an important Mendelian cause of IBD.  My research focuses on CGD as a translational disease model to explore the role of ROS in IBD. I am particularly interested in the interplay between the intestinal microbiota and mucosal immune system in order to gain a better understanding of the pathogenesis of CGD IBD and elucidate therapeutic targets.

Keywords

microbiome ; phagocyte ; innate immunity ; reactive oxygen species ; inflammation

Topics

  • chronic granulomatous disease
  • primary immunodeficiency
  • inflammatory bowel disease

Key Publications

Falcone EL, Holland SM.  Invasive fungal infection in chronic granulomatous disease: insights into pathogenesis and management.  Curr Opin Infect Dis. 2012 Dec;25(6):658-69.

Falcone EL, Zelazny AM, Holland SM.  Rothia aeria neck abscess in a patient with chronic granulomatous disease: case report and brief review of the literature.  J Clin Immunol. 2012 Dec;32(6):1400-3. 

Falcone EL, Hanses S, Stock F, Holland SM, Zelazny AM, Uzel G. Streptococcal infections in patients with chronic granulomatous disease: case   report and review of the literature.  J Clin Immunol. 2012 Aug;32(4):649-52.