Research
Supervisors: Professor Clare Bryant and Dr. Steven Holland (NIH/NIAID)
Chronic granulomatous disease (CGD) is an inherited immunodeficiency characterized by recurrent infections and inflammatory complications as a result of reduced phagocyte-mediated production of reactive oxygen species (ROS). The most common inflammatory complication in CGD is inflammatory bowel disease (IBD), affecting almost 50% of patients, making CGD an important Mendelian cause of IBD. My research focuses on CGD as a translational disease model to explore the role of ROS in IBD. I am particularly interested in the interplay between the intestinal microbiota and mucosal immune system in order to gain a better understanding of the pathogenesis of CGD IBD and elucidate therapeutic targets.
Publications
Falcone EL, Holland SM. Invasive fungal infection in chronic granulomatous disease: insights into pathogenesis and management. Curr Opin Infect Dis. 2012 Dec;25(6):658-69.
Falcone EL, Zelazny AM, Holland SM. Rothia aeria neck abscess in a patient with chronic granulomatous disease: case report and brief review of the literature. J Clin Immunol. 2012 Dec;32(6):1400-3.
Falcone EL, Hanses S, Stock F, Holland SM, Zelazny AM, Uzel G. Streptococcal infections in patients with chronic granulomatous disease: case report and review of the literature. J Clin Immunol. 2012 Aug;32(4):649-52.