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Cambridge Immunology Network



My lab studies how cells sense and respond to their oxygen and nutrient environments, and the implications for human disease. We use a combination of biochemical and genetic approaches to identify new components that influence cellular responses to oxygen and metabolites. Understanding how these components function may lead to pathways that can be exploited therapeutically to combat inflammatory disease and tumour growth.



Key publications: 

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJH, Lehner PJ, and Nathan JA. MARCH6 and TRC8 facilitate the quality control of cytosolic and tail anchored proteins. EMBO Reports 2018.

Miles AL*, Burr SP*, Grice GL, and Nathan JA. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels. eLife 2017. *equal contribution. Recommended on F1000

Burr SP, Costa ASH, Grice GL, Timms RT, Lobb IT, Freisigner P, Dodd RB, Dougan G, Lehner PJ, Frezza C, and Nathan JA. Mitochondrial protein lipoylation and the 2-oxoglutarate dehydrogenase complex controls HIF1α stability in aerobic conditions. Cell Metabolism 2016.

Grice GL, Lobb IT, Weekes MP, Gygi SP, Antrobus R, and Nathan JA. The proteasome distinguishes between heterotypic and homotypic lysine-11 linked polyubiquitin chains. Cell Reports 2015. 12(4):545-53. PMC4533228.

Link to more publications:

Dr James  Nathan
Takes PhD students
Not available for consultancy


Departments and institutes: 
Person keywords: 
cell biology
ubiquitin E3 ligase